Host hdac4 regulates the antiviral response by inhibiting the phosphorylation of irf3
文献类型：期刊论文
| 作者 | Yang, Qi1,2; Tang, Jielin1,2; Pei, Rongjuan1; Gao, XiaoXiao1,2; Guo, Jing1,2; Xu, Chonghui1,2; Wang, Yun1; Wang, Qian3; Wu, Chunchen1; Zhou, Yuan1 |
| 刊名 | Journal of molecular cell biology
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 11期号:2页码:158-169 |
| ISSN号 | 1674-2788 |
| 关键词 | Hdac4 Antiviral response Irf3 Tbk1 Ikke |
| DOI | 10.1093/jmcb/mjy035 |
| 通讯作者 | Chen, xinwen(chenxw@wh.iov.cn) ; Chen, jizheng(chenjz@wh.iov.cn) |
| 英文摘要 | Class ii hdacs, such as hdac4, are critical regulators of the immune response in various immune cells; however, its role in innate immunity remains largely unknown. here, we report that the overexpression of hdac4 suppresses the production of type i interferons triggered by pattern-recognition receptors (prrs). hdac4 repressed the translocation of transcription factor irf3 to the nucleus, thereby decreasing irf3-mediated ifn- expression. in particular, we also determined that hdac4 can be phosphorylated and simultaneously block the phosphorylation of irf3 at ser386 and ser396 by tbk1 and ikke, respectively, by interacting with the kinase domain of tbk1 and ikke. furthermore, ifn- may stimulate the expression of hdac4. our findings suggest that hdac4 acts as a regulator of prr signaling and is a novel mechanism of negative feedback regulation for preventing an over-reactive innate immune response. |
| WOS关键词 | HISTONE DEACETYLASE-4 ; NEGATIVE REGULATION ; GENE-EXPRESSION ; INTERFERON ; VIRUS ; INDUCTION ; DEGRADATION ; SIGNALS |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000462583700006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373164 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Xinwen; Chen, Jizheng |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Nanjing Med Univ, Sch Basic Med Sci, Key Lab Human Funct Genom Jiangsu Prov, Nanjing 210093, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Qi,Tang, Jielin,Pei, Rongjuan,et al. Host hdac4 regulates the antiviral response by inhibiting the phosphorylation of irf3[J]. Journal of molecular cell biology,2019,11(2):158-169. |
| APA | Yang, Qi.,Tang, Jielin.,Pei, Rongjuan.,Gao, XiaoXiao.,Guo, Jing.,...&Chen, Jizheng.(2019).Host hdac4 regulates the antiviral response by inhibiting the phosphorylation of irf3.Journal of molecular cell biology,11(2),158-169. |
| MLA | Yang, Qi,et al."Host hdac4 regulates the antiviral response by inhibiting the phosphorylation of irf3".Journal of molecular cell biology 11.2(2019):158-169. |
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来源：武汉病毒研究所
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