Characterization of a filovirus (mengla virus) from rousettus bats in china
文献类型：期刊论文
| 作者 | Yang, Xing-Lou1,2; Tan, Chee Wah2; Anderson, Danielle E.2; Jiang, Ren-Di1,3; Li, Bei1; Zhang, Wei1; Zhu, Yan1; Lim, Xiao Fang2; Zhou, Peng1; Liu, Xiang-Ling1 |
| 刊名 | Nature microbiology
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 4期号:3页码:390-395 |
| ISSN号 | 2058-5276 |
| DOI | 10.1038/s41564-018-0328-y |
| 通讯作者 | Wang, lin-fa(linfa.wang@duke-nus.edu.sg) ; Shi, zheng-li(zlshi@wh.iov.cn) |
| 英文摘要 | Filoviruses, especially ebola virus (ebov) and marburg virus (marv), are notoriously pathogenic and capable of causing severe haemorrhagic fever diseases in humans with high lethality(1/2). the risk of future outbreaks is exacerbated by the discovery of other bat-borne filoviruses of wide genetic diversity globally(3-5). here we report the characterization of a phylogenetically distinct bat filovirus, named mengla virus (mlav). the coding-complete genome of mlav shares 32-54% nucleotide sequence identity with known filoviruses. phylogenetic analysis places this new virus between ebov and marv, suggesting the need for a new genus taxon. importantly, despite the low amino acid sequence identity (22-39%) of the glycoprotein with other filoviruses, mlav is capable of using the niemann-pick c1 (npc1) as entry receptor. mlav is also replication-competent with chimeric mlav mini-genomes containing ebov or marv leader and trailer sequences, indicating that these viruses are evolutionally and functionally closely related. finally, mlav glycoprotein-typed pseudo-types transduced cell lines derived from humans, monkeys, dogs, hamsters and bats, implying a broad species cell tropism with a high risk of interspecies spillover transmission. |
| WOS关键词 | EBOLA-VIRUS ; ENTRY REQUIRES ; FRUIT BATS ; SYSTEM ; VP35 ; RNA |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000459201400007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373171 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Lin-Fa; Shi, Zheng-Li |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens, Wuhan, Hubei, Peoples R China 2.Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Guangdong Inst Appl Biol Resources, Guangzhou, Guangdong, Peoples R China 5.Wuhan Univ, Wuhan, Hubei, Peoples R China 6.Yunnan Inst Endem Dis Control & Prevent, Dali, Peoples R China 7.Dali Univ, Dali, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xing-Lou,Tan, Chee Wah,Anderson, Danielle E.,et al. Characterization of a filovirus (mengla virus) from rousettus bats in china[J]. Nature microbiology,2019,4(3):390-395. |
| APA | Yang, Xing-Lou.,Tan, Chee Wah.,Anderson, Danielle E..,Jiang, Ren-Di.,Li, Bei.,...&Shi, Zheng-Li.(2019).Characterization of a filovirus (mengla virus) from rousettus bats in china.Nature microbiology,4(3),390-395. |
| MLA | Yang, Xing-Lou,et al."Characterization of a filovirus (mengla virus) from rousettus bats in china".Nature microbiology 4.3(2019):390-395. |
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来源：武汉病毒研究所
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