Potent mers-cov fusion inhibitory peptides identified from hr2 domain in spike protein of bat coronavirus hku4
文献类型：期刊论文
| 作者 | Xia, Shuai1,2; Lan, Qiaoshuai1,2; Pu, Jing1,2; Wang, Cong1,2; Liu, Zezhong1,2; Xu, Wei1,2; Wang, Qian1,2; Liu, Huan3; Jiang, Shibo1,2,4; Lu, Lu1,2 |
| 刊名 | Viruses-basel
 |
| 出版日期 | 2019 |
| 卷号 | 11期号:1页码:12 |
| 关键词 | Mers-cov Fusion inhibitor Peptide Cell-cell fusion Hku4 |
| ISSN号 | 1999-4915 |
| DOI | 10.3390/v11010056 |
| 通讯作者 | Liu, huan(liuhuan@wh.iov.cn) ; Jiang, shibo(shibojiang@fudan.edu.cn) ; Lu, lu(lul@fudan.edu.cn) |
| 英文摘要 | The middle east respiratory syndrome coronavirus (mers-cov) emerged in 2012 and caused continual outbreaks worldwide with high mortality. however, no effective anti-mers-cov drug is currently available. recently, numerous evolutionary studies have suggested that mers-cov originated from bat coronavirus (batcov). we herein reported that three peptides derived from the hr2 region in spike protein of batcov hku4, including hku4-hr2p1, hku4-hr2p2 and hku4-hr2p3, could bind the mers-cov hr1-derived peptide to form a six-helix bundle (6-hb) with high stability. moreover, these peptides, particularly hku4-hr2p2 and hku4-hr2p3, exhibited potent inhibitory activity against mers-cov s-mediated cell-cell fusion and viral infection, suggesting that these hku4 hr2-derived peptides could be candidates for futher development as antiviral agents against mers-cov infection. |
| WOS关键词 | RESPIRATORY SYNDROME CORONAVIRUS ; TO-HUMAN TRANSMISSION ; ENTRY INHIBITORS ; RECEPTOR USAGE ; GP41 ; REGION ; CORE ; EVOLUTION |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000459132000055 |
| 出版者 | MDPI |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373176 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Liu, Huan; Jiang, Shibo; Lu, Lu |
| 作者单位 | 1.Fudan Univ, Key Lab Med Mol Virol MOE MOH, Sch Basic Med Sci, Shanghai 200032, Peoples R China 2.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 4.New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA |
| 推荐引用方式 GB/T 7714 | Xia, Shuai,Lan, Qiaoshuai,Pu, Jing,et al. Potent mers-cov fusion inhibitory peptides identified from hr2 domain in spike protein of bat coronavirus hku4[J]. Viruses-basel,2019,11(1):12. |
| APA | Xia, Shuai.,Lan, Qiaoshuai.,Pu, Jing.,Wang, Cong.,Liu, Zezhong.,...&Lu, Lu.(2019).Potent mers-cov fusion inhibitory peptides identified from hr2 domain in spike protein of bat coronavirus hku4.Viruses-basel,11(1),12. |
| MLA | Xia, Shuai,et al."Potent mers-cov fusion inhibitory peptides identified from hr2 domain in spike protein of bat coronavirus hku4".Viruses-basel 11.1(2019):12. |
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来源：武汉病毒研究所
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