Hsv-2 glycoprotein j promotes viral protein expression and virus spread
文献类型：期刊论文
| 作者 | Liu, Yalan1; Guan, Xinmeng1,2; Li, Chuntian1,2; Ni, Fengfeng1,2; Luo, Sukun4; Wang, Jun4; Zhang, Di1,2; Zhang, Mudan1; Hu, Qinxue1,3 |
| 刊名 | Virology
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 525页码:83-95 |
| ISSN号 | 0042-6822 |
| 关键词 | Hsv-2 Gj Cell-to-cell spread Protein expression Virus production |
| DOI | 10.1016/j.virol.2018.09.004 |
| 通讯作者 | Hu, qinxue(qhu@wh.iov.cn) |
| 英文摘要 | Hsv-2 spread is predominantly dependent on cell-to-cell contact. however, the underlying mechanisms remain to be determined. here we demonstrate that hsv-2 gj, which was previously assigned no specific function, promotes hsv-2 cell-to-cell spread and syncytia formation. in the context of viral infection, knockout or knockdown of gj impairs hsv-2 cell-to-cell spread among epithelial cells or from epithelial cells to neuronal cells, which leads to decreased virus production, whereas ectopic expression of gj enhances virus production. mechanistically, gj increases the expression levels of hsv-2 proteins, and also enhances viral protein expression and replication of heterologous viruses like hiv-1 and jev, suggesting that hsv-2 gj likely functions as a regulator of viral protein expression and virus production. findings in this study provide a basis for further understanding the role of gj in hsv-2 replication. |
| WOS关键词 | HERPES-SIMPLEX-VIRUS ; TO-CELL SPREAD ; FC-RECEPTORS ; APOPTOSIS ; ACTIVATION ; COMPLEX ; GENES ; WOMEN ; GM ; GE |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000452938600009 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373205 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Hu, Qinxue |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England 4.Huazhong Univ Sci & Technol, Tongli Med Coll, Wuhan Maternal & Child Healthcare Hosp, Wuhan Childrens Hosp, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yalan,Guan, Xinmeng,Li, Chuntian,et al. Hsv-2 glycoprotein j promotes viral protein expression and virus spread[J]. Virology,2018,525:83-95. |
| APA | Liu, Yalan.,Guan, Xinmeng.,Li, Chuntian.,Ni, Fengfeng.,Luo, Sukun.,...&Hu, Qinxue.(2018).Hsv-2 glycoprotein j promotes viral protein expression and virus spread.Virology,525,83-95. |
| MLA | Liu, Yalan,et al."Hsv-2 glycoprotein j promotes viral protein expression and virus spread".Virology 525(2018):83-95. |
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来源：武汉病毒研究所
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