Histone deacetylase 3 inhibitor suppresses hepatitis c virus replication by regulating apo-a1 and leap-1 expression
文献类型：期刊论文
| 作者 | Zhou, Yuan1; Wang, Qian3; Yang, Qi1,2; Tang, Jielin1,2; Xu, Chonghui1,2; Gai, Dongwei1,2; Chen, Xinwen1; Chen, Jizheng1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 33期号:5页码:418-428 |
| 关键词 | Hepatitis c virus (hcv) Hdac3 Apolipoprotein-a1(apo-a1) Leap-1 Hepatocellular carcinoma Viral replication |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-018-0057-7 |
| 通讯作者 | Chen, jizheng(chenjz@wh.iov.cn) |
| 英文摘要 | Histone deacetylase (hdac) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (hcc). in this study, we investigated the effect of hdac inhibitor treatment on hepatitis c virus (hcv) replication in huh7 human liver cells and in a mouse model of hcv infection. viral replication was markedly suppressed by the hdac3 inhibitor at concentrations below 1mmol/l, with no cellular toxicity. this was accompanied by upregulation of liver-expressed antimicrobial peptide 1(leap-1) and downregulation of apolipoprotein-a1 (apo-a1), as determined by microarray and quantitative rt-pcr analyses. moreover, hdac3 was found to modulate the binding of ccaat-enhancer-binding protein (c/ebp), hypoxia-inducible factor 1 (hif1), and signal transducer and activator of transcription 3 (stat3) to the leap-1 promoter. hdac3 inhibitor treatment also blocked hcv replication in a mouse model of hcv infection. these results indicate that epigenetic therapy with hdac3 inhibitor may be a potential treatment for diseases associated with hcv infection such as hcc. |
| WOS关键词 | CYTOSOLIC PHOSPHOLIPASE-A2 GAMMA ; IRON ; NORMALIZATION ; TRANSCRIPTION ; HOMEOSTASIS ; PHLEBOTOMY ; STAT3 |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000450634200006 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373216 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Jizheng |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100101, Peoples R China 3.Nanjing Med Univ, Dept Biochem & Mol Biol, Jiangsu Prov Key Lab Human Funct Genom, Nanjing 210029, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yuan,Wang, Qian,Yang, Qi,et al. Histone deacetylase 3 inhibitor suppresses hepatitis c virus replication by regulating apo-a1 and leap-1 expression[J]. Virologica sinica,2018,33(5):418-428. |
| APA | Zhou, Yuan.,Wang, Qian.,Yang, Qi.,Tang, Jielin.,Xu, Chonghui.,...&Chen, Jizheng.(2018).Histone deacetylase 3 inhibitor suppresses hepatitis c virus replication by regulating apo-a1 and leap-1 expression.Virologica sinica,33(5),418-428. |
| MLA | Zhou, Yuan,et al."Histone deacetylase 3 inhibitor suppresses hepatitis c virus replication by regulating apo-a1 and leap-1 expression".Virologica sinica 33.5(2018):418-428. |
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来源：武汉病毒研究所
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