Countrywide survey for mers-coronavirus antibodies in dromedaries and humans in pakistan
文献类型：期刊论文
| 作者 | Zohaib, Ali1,2; Saqib, Muhammad3; Athar, Muhammad Ammar4; Chen, Jing1; Sial, Awais-ur-Rahman5; Khan, Saeed6; Taj, Zeeshan7; Sadia, Halima8; Tahir, Usman8; Tayyab, Muhammad Haleem3 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2018-10-01 |
| 卷号 | 33期号:5页码:410-417 |
| ISSN号 | 1674-0769 |
| 关键词 | Middle east respiratory syndrome coronavirus (mers-cov) Camel Human Pakistan |
| DOI | 10.1007/s12250-018-0051-0 |
| 通讯作者 | Shi, zheng-li(zlshi@wh.iov.cn) |
| 英文摘要 | Middle east respiratory syndrome coronavirus (mers-cov) is a zoonotic pathogen capable of causing severe respiratory disease in humans. although dromedary camels are considered as a major reservoir host, the mers-cov infection dynamics in camels are not fully understood. through surveillance in pakistan, nasal (n=776) and serum (n=1050) samples were collected from camels between november 2015 and february 2018. samples were collected from animal markets, free-roaming herds and abattoirs. an in-house elisa was developed to detect igg against mers-cov. a total of 794 camels were found seropositive for mers-cov. prevalence increased with the age and the highest seroprevalence was recorded in camels aged>10years (81.37%) followed by those aged 3.1-10years (78.65%) and3years (58.19%). higher prevalence was observed in female (78.13%) as compared to male (70.70%). of the camel nasal swabs, 22 were found to be positive by rt-qpcr though with high ct values. moreover, 2,409 human serum samples were also collected from four provinces of pakistan during 2016-2017. among the sampled population, 840 humans were camel herders. although we found a high rate of mers-cov antibody positive dromedaries (75.62%) in pakistan, no neutralizing antibodies were detected in humans with and without contact to camels. |
| WOS关键词 | EAST RESPIRATORY SYNDROME ; SEROLOGIC EVIDENCE ; SAUDI-ARABIA ; CAMELS ; INFECTION ; AFRICA ; ABSENCE ; REGION ; KENYA ; RISK |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000450634200005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373218 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zheng-Li |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Agr Faisalabad, Fac Vet Med, Faisalabad 38040, Pakistan 4.Henan Univ, Coll Pharm, Lab Canc Biomarkers & Liquid Biopsy, Kaifeng 475004, Henan, Peoples R China 5.PMAS Arid Agr Univ, Fac Vet & Anim Sci, Dept Clin Studies, Rawalpindi 46000, Pakistan 6.Dow Univ Hlth Sci, Karachi 74200, Pakistan 7.Govt Coll Univ Faisalabad, Dept Microbiol, Faisalabad 38000, Pakistan 8.Livestock & Dairy Dev Dept L&DD, Lahore 54000, Pakistan 9.Islamia Univ Bahawalpur, Coll Vet & Anim Sci, Bahawalpur 63100, Pakistan 10.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zohaib, Ali,Saqib, Muhammad,Athar, Muhammad Ammar,et al. Countrywide survey for mers-coronavirus antibodies in dromedaries and humans in pakistan[J]. Virologica sinica,2018,33(5):410-417. |
| APA | Zohaib, Ali.,Saqib, Muhammad.,Athar, Muhammad Ammar.,Chen, Jing.,Sial, Awais-ur-Rahman.,...&Shi, Zheng-Li.(2018).Countrywide survey for mers-coronavirus antibodies in dromedaries and humans in pakistan.Virologica sinica,33(5),410-417. |
| MLA | Zohaib, Ali,et al."Countrywide survey for mers-coronavirus antibodies in dromedaries and humans in pakistan".Virologica sinica 33.5(2018):410-417. |
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来源：武汉病毒研究所
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