Pla1a participates in the antiviral innate immune response by facilitating the recruitment of tank-binding kinase 1 to mitochondria
文献类型：期刊论文
| 作者 | Gao, Xiaoxiao1,2; Chen, Dan1,2; Hu, Xue1; Zhou, Yuan1; Wang, Yun1; Wu, Chunchen1; Chen, Jizheng1; Wang, Yanyi1; Pei, Rongjuan1; Chen, Xinwen1 |
| 刊名 | Journal of innate immunity
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:4页码:315-327 |
| 关键词 | Antiviral innate immune response Pla1a Tank-binding kinase 1 Mitochondria |
| ISSN号 | 1662-811X |
| DOI | 10.1159/000489832 |
| 通讯作者 | Pei, rongjuan(rongjuan_pei@wh.iov.cn) ; Chen, xinwen(chenxw@wh.iov.cn) |
| 英文摘要 | As a key molecule in the antiviral innate immune response, the activation of tank-binding kinase 1 (tbk1) is under tight regulation. in this report, we identified phosphatidylserine-specific phospholipase pla1a as a host factor that modulates the tbk1 activation. knockdown of pla1a expression suppressed the innate immune signaling induced by rna viruses, while pla1a overexpression enhanced the signaling. pla1a functioned at the tbk1 level of the signaling pathway, as pla1a silencing blocked tbk1, but not interferon regulatory factor 3 (irf3) induced interferon-beta (ifn-beta) promoter activity. the phosphorylation and kinase activity of tbk1 was reduced in pla1a knockdown cells. mechanistically, pla1a was required in tbk1-mitochondrial antiviral signaling protein (mavs) interactions but not the interactions of tbk1 with other adaptor proteins. furthermore, pla1a knockdown reduced the recruitment of tbk1 and irf3 to mitochondria, concomitant with altered mitochondria morphology. (c) 2018 s. karger ag, basel |
| WOS关键词 | IFN-BETA PRODUCTION ; I INTERFERON ; COMPLEX-FORMATION ; TBK1 ; ACTIVATION ; PROTEIN ; UBIQUITINATION ; DEGRADATION ; INSIGHTS ; IRF3 |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000445951800007 |
| 出版者 | KARGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373237 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Pei, Rongjuan; Chen, Xinwen |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Xiaoxiao,Chen, Dan,Hu, Xue,et al. Pla1a participates in the antiviral innate immune response by facilitating the recruitment of tank-binding kinase 1 to mitochondria[J]. Journal of innate immunity,2018,10(4):315-327. |
| APA | Gao, Xiaoxiao.,Chen, Dan.,Hu, Xue.,Zhou, Yuan.,Wang, Yun.,...&Chen, Xinwen.(2018).Pla1a participates in the antiviral innate immune response by facilitating the recruitment of tank-binding kinase 1 to mitochondria.Journal of innate immunity,10(4),315-327. |
| MLA | Gao, Xiaoxiao,et al."Pla1a participates in the antiviral innate immune response by facilitating the recruitment of tank-binding kinase 1 to mitochondria".Journal of innate immunity 10.4(2018):315-327. |
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来源：武汉病毒研究所
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