Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models
文献类型：期刊论文
| 作者 | Xu, Jingjing1,2; Yang, Hang3; Bi, Yongli1,2; Li, Wuyou1,2; Wei, Hongping3; Li, Yuhong1,2 |
| 刊名 | Viruses-basel
 |
| 出版日期 | 2018-07-01 |
| 卷号 | 10期号:7页码:13 |
| ISSN号 | 1999-4915 |
| 关键词 | Dental caries Bacteriophage lysin Biofilm Antibacterial Anticaries |
| DOI | 10.3390/v10070380 |
| 通讯作者 | Li, yuhong(1004809372@whu.edu.cn) |
| 英文摘要 | Dental caries is a common disease caused by oral bacteria. streptococcus mutans and streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. in this study, we evaluated the activity of clyr, a well-known chimeric lysin with extended streptococcal host range, against common gram-positive oral microbes and its anticaries efficacy in rat models. clyr demonstrated high lytic activity against s. mutans mt8148 and s. sobrinus atcc6715, with minor activity against streptococcus sanguinis, streptococcus oralis, and streptococcus salivarius, which are considered as harmless commensal oral bacteria. confocal laser scanning microscopy showed that the number of viable cells in 72-h aged s. mutans and s. sobrinus biofilms are significantly (p < 0.05) decreased after treatment with 50 mu g/ml clyr for 5 min. furthermore, continuous administration of clyr for 40 days (5 mu g/day) significantly (p < 0.05) reduced the severity of caries in rat models infected with a single or a mixed bacteria of s. mutans and s. sobrinus. therefore, clyr could be a promising agent or additive for the prevention and treatment of dental caries. |
| WOS关键词 | RESISTANT STAPHYLOCOCCUS-AUREUS ; STREPTOCOCCUS-MUTANS ; DENTAL-CARIES ; DRUG-RESISTANT ; IN-VITRO ; BIOFILM ; SOBRINUS ; INFECTION ; SCHOOLCHILDREN ; PEPTIDOGLYCAN |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | MDPI |
| WOS记录号 | WOS:000445153200042 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373239 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, Yuhong |
| 作者单位 | 1.Wuhan Univ, Sch Stomatol, Minist Educ, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Hubei, Peoples R China 2.Wuhan Univ, Sch Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jingjing,Yang, Hang,Bi, Yongli,et al. Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models[J]. Viruses-basel,2018,10(7):13. |
| APA | Xu, Jingjing,Yang, Hang,Bi, Yongli,Li, Wuyou,Wei, Hongping,&Li, Yuhong.(2018).Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models.Viruses-basel,10(7),13. |
| MLA | Xu, Jingjing,et al."Activity of the chimeric lysin clyr against common gram-positive oral microbes and its anticaries efficacy in rat models".Viruses-basel 10.7(2018):13. |
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来源：武汉病毒研究所
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