中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors

文献类型:期刊论文

作者Lian, Huan1; Zang, Ru1; Wei, Jin1; Ye, Wen1; Hu, Ming-Ming1; Chen, Yun-Da1,2; Zhang, Xia-Nan1,2; Guo, Yi1,2; Lei, Cao-Qi1,2; Yang, Qing1
刊名Immunity
出版日期2018-09-18
卷号49期号:3页码:438-+
ISSN号1074-7613
DOI10.1016/j.immuni.2018.08.014
通讯作者Li, shu(shuli@whu.edu.cn) ; Shu, hong-bing(shuh@whu.edu.cn)
英文摘要Recognition of viral rna by the retinoic acid-inducible gene-i (rig-i)-like receptors (rlrs) initiates innate antiviral immune response. how the binding of viral rna to and activation of the rlrs are regulated remains enigmatic. in this study, we identified zcchc3 as a positive regulator of the rlrs including rig-i and mda5. zcchc3 deficiency markedly inhibited rna virus-triggered induction of downstream antiviral genes, and zcchc3-deficient mice were more susceptible to rna virus infection. zcchc3 was associated with rig-i and mda5 and functions in two distinct processes for regulation of rig-i and mda5 activities. zcchc3 bound to dsrna and enhanced the binding of rig-i and mda5 to dsrna. zcchc3 also recruited the e3 ubiquitin ligase trim25 to the rig-i and mda5 complexes to facilitate its k63-linked polyubiquitination and activation. thus, zcchc3 is a co-receptor for rig-i and mda5, which is critical for rlr-mediated innate immune response to rna virus.
WOS关键词CELLULAR ANTIVIRAL RESPONSE ; INNATE IMMUNE-RESPONSE ; NF-KAPPA-B ; IFN-BETA ; RECOGNITION ; VIRUS ; MDA5 ; UBIQUITINATION ; IRF3 ; PHOSPHORYLATION
WOS研究方向Immunology
WOS类目Immunology
语种英语
出版者CELL PRESS
WOS记录号WOS:000444909600012
URI标识http://www.irgrid.ac.cn/handle/1471x/2373240
专题武汉病毒研究所
通讯作者Li, Shu; Shu, Hong-Bing
作者单位1.Wuhan Univ, Med Res Inst, Sch Med, Wuhan 430071, Peoples R China
2.Wuhan Univ, Life Sci, Wuhan 430072, Peoples R China
3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China
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GB/T 7714
Lian, Huan,Zang, Ru,Wei, Jin,et al. The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors[J]. Immunity,2018,49(3):438-+.
APA Lian, Huan.,Zang, Ru.,Wei, Jin.,Ye, Wen.,Hu, Ming-Ming.,...&Shu, Hong-Bing.(2018).The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors.Immunity,49(3),438-+.
MLA Lian, Huan,et al."The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors".Immunity 49.3(2018):438-+.

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来源:武汉病毒研究所

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