The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors
文献类型:期刊论文
作者 | Lian, Huan1; Zang, Ru1; Wei, Jin1; Ye, Wen1; Hu, Ming-Ming1; Chen, Yun-Da1,2; Zhang, Xia-Nan1,2; Guo, Yi1,2; Lei, Cao-Qi1,2; Yang, Qing1 |
刊名 | Immunity |
出版日期 | 2018-09-18 |
卷号 | 49期号:3页码:438-+ |
ISSN号 | 1074-7613 |
DOI | 10.1016/j.immuni.2018.08.014 |
通讯作者 | Li, shu(shuli@whu.edu.cn) ; Shu, hong-bing(shuh@whu.edu.cn) |
英文摘要 | Recognition of viral rna by the retinoic acid-inducible gene-i (rig-i)-like receptors (rlrs) initiates innate antiviral immune response. how the binding of viral rna to and activation of the rlrs are regulated remains enigmatic. in this study, we identified zcchc3 as a positive regulator of the rlrs including rig-i and mda5. zcchc3 deficiency markedly inhibited rna virus-triggered induction of downstream antiviral genes, and zcchc3-deficient mice were more susceptible to rna virus infection. zcchc3 was associated with rig-i and mda5 and functions in two distinct processes for regulation of rig-i and mda5 activities. zcchc3 bound to dsrna and enhanced the binding of rig-i and mda5 to dsrna. zcchc3 also recruited the e3 ubiquitin ligase trim25 to the rig-i and mda5 complexes to facilitate its k63-linked polyubiquitination and activation. thus, zcchc3 is a co-receptor for rig-i and mda5, which is critical for rlr-mediated innate immune response to rna virus. |
WOS关键词 | CELLULAR ANTIVIRAL RESPONSE ; INNATE IMMUNE-RESPONSE ; NF-KAPPA-B ; IFN-BETA ; RECOGNITION ; VIRUS ; MDA5 ; UBIQUITINATION ; IRF3 ; PHOSPHORYLATION |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
语种 | 英语 |
出版者 | CELL PRESS |
WOS记录号 | WOS:000444909600012 |
URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373240 |
专题 | 武汉病毒研究所 |
通讯作者 | Li, Shu; Shu, Hong-Bing |
作者单位 | 1.Wuhan Univ, Med Res Inst, Sch Med, Wuhan 430071, Peoples R China 2.Wuhan Univ, Life Sci, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Peoples R China |
推荐引用方式 GB/T 7714 | Lian, Huan,Zang, Ru,Wei, Jin,et al. The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors[J]. Immunity,2018,49(3):438-+. |
APA | Lian, Huan.,Zang, Ru.,Wei, Jin.,Ye, Wen.,Hu, Ming-Ming.,...&Shu, Hong-Bing.(2018).The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors.Immunity,49(3),438-+. |
MLA | Lian, Huan,et al."The zinc-finger protein zcchc3 binds rna and facilitates viral rna sensing and activation of the rig-i-like receptors".Immunity 49.3(2018):438-+. |
入库方式: iSwitch采集
来源:武汉病毒研究所
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