Hepatitis b virus infection: defective surface antigen expression and pathogenesis
文献类型：期刊论文
| 作者 | Wu, Chun-Chen1; Chen, Ying-Shan1; Cao, Liang1,2; Chen, Xin-Wen1; Lu, Meng-Ji3 |
| 刊名 | World journal of gastroenterology
 |
| 出版日期 | 2018-08-21 |
| 卷号 | 24期号:31页码:3488-3499 |
| 关键词 | Hepatitis b surface protein Defective surface antigen mutants Endoplasmic reticulum stress Fulminant hepatitis b Occult hepatitis b virus infection Pathogenesis |
| ISSN号 | 1007-9327 |
| DOI | 10.3748/wjg.v24.i31.3488 |
| 通讯作者 | Lu, meng-ji(mengji.lu@uni-due.de) |
| 英文摘要 | Hepatitis b virus (hbv) infection is a global public health concern. hbv causes chronic infection in patients and can lead to liver cirrhosis, hepatocellular carcinoma, and other severe liver diseases. thus, understanding hbv-related pathogenesis is of particular importance for prevention and clinical intervention. hbv surface antigens are indispensable for hbv virion formation and are useful viral markers for diagnosis and clinical assessment. during chronic hbv infection, hbv genomes may acquire and accumulate mutations and deletions, leading to the expression of defective hbv surface antigens. these defective hbv surface antigens have been found to play important roles in the progression of hbv-associated liver diseases. in this review, we focus our discussion on the nature of defective hbv surface antigen mutations and their contribution to the pathogenesis of fulminant hepatitis b. the relationship between defective surface antigens and occult hbv infection are also discussed. |
| WOS关键词 | ENDOPLASMIC-RETICULUM STRESS ; AMINO-ACID SUBSTITUTIONS ; CLOSED CIRCULAR DNA ; LIVER-TRANSPLANT RECIPIENTS ; LARGE ENVELOPE POLYPEPTIDE ; UNFOLDED PROTEIN RESPONSE ; INDUCED ESCAPE MUTANT ; CHRONIC HBV INFECTION ; VIVO HBSAG CLEARANCE ; PRE-S DELETION |
| WOS研究方向 | Gastroenterology & Hepatology |
| WOS类目 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000441879700003 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373247 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Lu, Meng-Ji |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Northwestern Univ, Dept Microbiol & Immunol, Feinberg Sch Med, Chicago, IL 60611 USA 3.Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45122 Essen, Germany |
| 推荐引用方式 GB/T 7714 | Wu, Chun-Chen,Chen, Ying-Shan,Cao, Liang,et al. Hepatitis b virus infection: defective surface antigen expression and pathogenesis[J]. World journal of gastroenterology,2018,24(31):3488-3499. |
| APA | Wu, Chun-Chen,Chen, Ying-Shan,Cao, Liang,Chen, Xin-Wen,&Lu, Meng-Ji.(2018).Hepatitis b virus infection: defective surface antigen expression and pathogenesis.World journal of gastroenterology,24(31),3488-3499. |
| MLA | Wu, Chun-Chen,et al."Hepatitis b virus infection: defective surface antigen expression and pathogenesis".World journal of gastroenterology 24.31(2018):3488-3499. |
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来源：武汉病毒研究所
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