Zcchc3 is a co-sensor of cgas for dsdna recognition in innate immune response
文献类型：期刊论文
| 作者 | Lian, Huan1; Wei, Jin1; Zang, Ru1; Ye, Wen1; Yang, Qing1; Zhang, Xia-Nan1,2; Chen, Yun-Da1,2; Fu, Yu-Zhi3; Hu, Ming-Ming1; Lei, Cao-Qi1,2 |
| 刊名 | Nature communications
 |
| 出版日期 | 2018-08-22 |
| 卷号 | 9页码:13 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-05559-w |
| 通讯作者 | Li, shu(shuli@whu.edu.cn) ; Shu, hong-bing(shuh@whu.edu.cn) |
| 英文摘要 | Cyclic gmp-amp synthase (cgas) senses double-strand (ds) dna in the cytosol and then catalyzes synthesis of the second messenger cgamp, which activates the adaptor mita/sting to initiate innate antiviral response. how cgas activity is regulated remains enigmatic. here, we identify zcchc3, a cchc-type zinc-finger protein, as a positive regulator of cytosolic dsdna-and dna virus-triggered signaling. we show that zcchc3-deficiency inhibits dsdna-and dna virus-triggered induction of downstream effector genes, and that zcchc3-deficient mice are more susceptible to lethal herpes simplex virus type 1 or vaccinia virus infection. zcchc3 directly binds to dsdna, enhances the binding of cgas to dsdna, and is important for cgas activation following viral infection. our results suggest that zcchc3 is a co-sensor for recognition of dsdna by cgas, which is important for efficient innate immune response to cytosolic dsdna and dna virus. |
| WOS关键词 | CYCLIC GMP-AMP ; CYTOSOLIC DNA SENSOR ; INTRACELLULAR DNA ; DENDRITIC CELLS ; MYCOBACTERIUM-TUBERCULOSIS ; ANTIVIRAL RESPONSE ; I INTERFERONS ; ADAPTER ; SYNTHASE ; 2ND-MESSENGER |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000442375000002 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373248 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Li, Shu; Shu, Hong-Bing |
| 作者单位 | 1.Wuhan Univ, Med Res Inst, Sch Med, Wuhan 430071, Hubei, Peoples R China 2.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lian, Huan,Wei, Jin,Zang, Ru,et al. Zcchc3 is a co-sensor of cgas for dsdna recognition in innate immune response[J]. Nature communications,2018,9:13. |
| APA | Lian, Huan.,Wei, Jin.,Zang, Ru.,Ye, Wen.,Yang, Qing.,...&Shu, Hong-Bing.(2018).Zcchc3 is a co-sensor of cgas for dsdna recognition in innate immune response.Nature communications,9,13. |
| MLA | Lian, Huan,et al."Zcchc3 is a co-sensor of cgas for dsdna recognition in innate immune response".Nature communications 9(2018):13. |
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来源：武汉病毒研究所
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