Trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis
文献类型：期刊论文
| 作者 | Zhang, Hong-Xia1,2; Xu, Zhi-Sheng3,4; Lin, Hen1; Li, Mi1; Xia, Tian1; Cui, Kaisa1; Wang, Su-Yun4; Li, Youjun1; Shu, Hong-Bing1,2; Wang, Yan-Yi4 |
| 刊名 | Nature communications
 |
| 出版日期 | 2018-08-24 |
| 卷号 | 9页码:16 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-05796-z |
| 通讯作者 | Shu, hong-bing(shuh@whu.edu.cn) ; Wang, yan-yi(wangyy@wh.iov.cn) |
| 英文摘要 | Stat3 is a transcription factor that plays central roles in various physiological processes and its deregulation results in serious diseases including cancer. the mechanisms on how stat3 activity is regulated remains enigmatic. here we identify trim27 as a positive regulator of ii6-induced stat3 activation and downstream gene expression. trim27 localizes to retromer-positive punctate structures and serves as a critical link for recruiting gp130, jak1, and stat3 to and subsequent phosphorylation of stat3 at the retromer-positive structures. overexpression of trim27 promotes cancer cell growth in vitro and tumor growth in nude mice, whereas knockdown of trim27 has opposite effects. deficiency of trim27 significantly impairs dextran sulfate sodium (dss)-induced stat3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (aom)/dss-induced colitis-associated cancer in mice. these findings reveal a retromer-dependent mechanism for regulation of stat3 activation, inflammation, and inflammation-associated cancer development. |
| WOS关键词 | RET FINGER PROTEIN ; UBIQUITIN LIGASE TRIM27 ; INNATE IMMUNE-RESPONSE ; INTESTINAL INFLAMMATION ; TBK1 DEGRADATION ; IL-6 PRODUCTION ; MOUSE MODEL ; CANCER ; EXPRESSION ; TUMORIGENESIS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000442595700002 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373249 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shu, Hong-Bing; Wang, Yan-Yi |
| 作者单位 | 1.Wuhan Univ, Coll Life Sci, Wuhan 430072, Hubei, Peoples R China 2.Wuhan Univ, Med Res Inst, Sch Med, Wuhan 430071, Hubei, Peoples R China 3.Guangzhou Women & Childrens Med Ctr, Guangzhou Inst Pediat, Joint Ctr Translat Precis Med, Guangzhou 510623, Guangdong, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hong-Xia,Xu, Zhi-Sheng,Lin, Hen,et al. Trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis[J]. Nature communications,2018,9:16. |
| APA | Zhang, Hong-Xia.,Xu, Zhi-Sheng.,Lin, Hen.,Li, Mi.,Xia, Tian.,...&Wang, Yan-Yi.(2018).Trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis.Nature communications,9,16. |
| MLA | Zhang, Hong-Xia,et al."Trim27 mediates stat3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis".Nature communications 9(2018):16. |
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来源：武汉病毒研究所
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