The regulation of cgas
文献类型：期刊论文
| 作者 | Xiong, Meiguang; Wang, Suyun; Wang, Yan-Yi; Ran, Yong |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 33期号:2页码:117-124 |
| ISSN号 | 1674-0769 |
| 关键词 | Cgas Dna sensing Regulation Autoimmune |
| DOI | 10.1007/s12250-018-0005-6 |
| 通讯作者 | Ran, yong(ranyong@wh.iov.cn) |
| 英文摘要 | The cgas-mita pathway of cytosolic dna sensing plays essential roles in immune response against pathogens that contain dna or with dna production in their life cycles. the cgas-mita pathway also detects leaked or aberrant accumulated self dna in the cytoplasm under certain pathological conditions, such as virus induced cell death, dna damage, mitochondria damage, gene mutations, which results in autoimmune diseases. therefore, the cgas-mita pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. the regulation of cgas-mita pathway at mita-level have been extensively explored and reviewed elsewhere, here we provide a summary and perspective on recent advances in understanding of the cgas regulation. |
| WOS关键词 | CYCLIC GMP-AMP ; DNA SENSOR CGAS ; INNATE IMMUNE-RESPONSE ; CYTOSOLIC DNA ; SENSING PATHWAY ; STING PATHWAY ; ACTIVATION ; PROTEIN ; SYNTHASE ; VIRUS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000431413000001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373270 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ran, Yong |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Meiguang,Wang, Suyun,Wang, Yan-Yi,et al. The regulation of cgas[J]. Virologica sinica,2018,33(2):117-124. |
| APA | Xiong, Meiguang,Wang, Suyun,Wang, Yan-Yi,&Ran, Yong.(2018).The regulation of cgas.Virologica sinica,33(2),117-124. |
| MLA | Xiong, Meiguang,et al."The regulation of cgas".Virologica sinica 33.2(2018):117-124. |
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来源：武汉病毒研究所
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