Development of a novel rhesus macaque model with an infectious r5 simian-human immunodeficiency virus encoding hiv-1 crf08_bc env
文献类型：期刊论文
| 作者 | Huang, Li1; Kusagawa, Shigeru2; Zeng, Haiyan1; Yang, Guibo3; Sun, Binlian1; Miura, Tomoyuki4; Yang, Rongge1 |
| 刊名 | Journal of medical primatology
 |
| 出版日期 | 2014-02-01 |
| 卷号 | 43期号:1页码:11-21 |
| ISSN号 | 0047-2565 |
| 关键词 | Chinese rhesus macaques Crf08_bc Peripheral blood mononuclear cell R5 Simian-human immunodeficiency virus |
| DOI | 10.1111/jmp.12084 |
| 通讯作者 | Yang, rongge(ryang@wh.iov.cn) |
| 英文摘要 | Backgroundthe crf08_bc strain is one of the most predominant circulating human immunodeficiency virus type 1 (hiv-1) strains in the chinese pandemic. a simian-human immunodeficiency virus (shiv) encoding hiv-1 crf08_bc env is highly desirable to evaluate candidate aids vaccines in non-human primates. methodsshiv-kbqj-12, which carries the envelope glycoprotein from qj001, an infectious molecular clone of hiv-1 crf08_bc, was generated. the replication capacity of shiv-kbqj-12 was determined both in human and rhesus macaque (macaca mulatta) peripheral blood mononuclear cells (pbmcs) and in chinese rhesus macaques. resultsshiv-kbqj-12 replicated efficiently in human and macaque pbmcs and displayed a preference for ccr5 as an entry coreceptor. productive infection of two macaques by intravenous inoculation with shiv-kbqj-12 was confirmed. conclusionsshiv-kbqj-12 is an r5-tropic chimeric virus that can establish productive infection both in vitro and in vivo in chinese rhesus macaques and will be useful to assess candidate hiv-1 crf08_bc vaccines in china. |
| WOS关键词 | T-LYMPHOCYTE DEPLETION ; PIG-TAILED MACAQUES ; TYPE-1 SUBTYPE-C ; ENVELOPE GLYCOPROTEINS ; REPLICATION-COMPETENT ; AIDS ; MONKEYS ; ISOLATE ; VACCINE ; SHIV |
| WOS研究方向 | Veterinary Sciences ; Zoology |
| WOS类目 | Veterinary Sciences ; Zoology |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000329307500002 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373275 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Yang, Rongge |
| 作者单位 | 1.Chinese Acad Sci, Res Grp HIV Mol Epidemiol & Virol, Ctr Emerging Infect Dis, State Key Lab Virol,Wuhan Inst Virol, Wuhan 430071, Peoples R China 2.Natl Inst Infect Dis, AIDS Res Ctr, Lab Virol & Diag, Tokyo, Japan 3.China Ctr Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Beijing, Peoples R China 4.Kyoto Univ, Inst Virus Res, Expt Res Ctr Infect Dis, Lab Primate Model, Kyoto 606, Japan |
| 推荐引用方式 GB/T 7714 | Huang, Li,Kusagawa, Shigeru,Zeng, Haiyan,et al. Development of a novel rhesus macaque model with an infectious r5 simian-human immunodeficiency virus encoding hiv-1 crf08_bc env[J]. Journal of medical primatology,2014,43(1):11-21. |
| APA | Huang, Li.,Kusagawa, Shigeru.,Zeng, Haiyan.,Yang, Guibo.,Sun, Binlian.,...&Yang, Rongge.(2014).Development of a novel rhesus macaque model with an infectious r5 simian-human immunodeficiency virus encoding hiv-1 crf08_bc env.Journal of medical primatology,43(1),11-21. |
| MLA | Huang, Li,et al."Development of a novel rhesus macaque model with an infectious r5 simian-human immunodeficiency virus encoding hiv-1 crf08_bc env".Journal of medical primatology 43.1(2014):11-21. |
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来源：武汉病毒研究所
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