Effect of huperzine-a, a novel acetylcholinesterase inhibitor, on radial maze performance in rats
文献类型：期刊论文
| 作者 | XIONG, ZQ; TANG, XC |
| 刊名 | Pharmacology biochemistry and behavior
 |
| 出版日期 | 1995-06-01 |
| 卷号 | 51期号:2-3页码:415-419 |
| 关键词 | Huperzine a Physostigmine Scopolamine Mecamylamine Working memory Reference memory Radial maze Cholinesterase inhibitor |
| ISSN号 | 0091-3057 |
| 英文摘要 | Rats were trained to run in a spatial, radial arm maze using a procedure to determine two memory functions, working and reference memory. the muscarinic antagonist, not the nicotinic antagonist, impaired both working and reference memory of rats. scopolamine (0.125, 0.15, and 0.2 mg/kg, ip, 30 min before a session) significantly impaired choice accuracy in the eight-arm maze. in contrast, mecamylamine (5, 10, and 15 mg/kg) did not affect the performance. huperzine a (0.1, 0.2, and 0.3 mg/kg, if, 30 min before testing) and physostigmine (0.3 mg/kg, if, 20 min before testing) could reverse scopolamine-induced deficits in the task. chronic treatment with huperzine a (0.25 mg/kg, po, once a day) for 8 consecutive days was as potent as acute treatment on attenuating the scopolamine-induced amnesia. |
| WOS关键词 | REFERENCE MEMORY ; PHYSOSTIGMINE ; SCOPOLAMINE ; TACRINE ; WORKING ; SYSTEM |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| WOS类目 | Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995RB49100039 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373279 |
| 专题 | 武汉病毒研究所 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | XIONG, ZQ,TANG, XC. Effect of huperzine-a, a novel acetylcholinesterase inhibitor, on radial maze performance in rats[J]. Pharmacology biochemistry and behavior,1995,51(2-3):415-419. |
| APA | XIONG, ZQ,&TANG, XC.(1995).Effect of huperzine-a, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.Pharmacology biochemistry and behavior,51(2-3),415-419. |
| MLA | XIONG, ZQ,et al."Effect of huperzine-a, a novel acetylcholinesterase inhibitor, on radial maze performance in rats".Pharmacology biochemistry and behavior 51.2-3(1995):415-419. |
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来源：武汉病毒研究所
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