Development of natural-products as drugs acting on central-nervous-system
文献类型：期刊论文
| 作者 | ZHU, XZ |
| 刊名 | Memorias do instituto oswaldo cruz
 |
| 出版日期 | 1991 |
| 卷号 | 86页码:173-175 |
| 关键词 | Tetrahydroprotoberberines 3-acetylaconitine Huperzine-a Ranamargarin Analgesia Dopamine receptor antagonists Cholinesterase inhibitors |
| ISSN号 | 0074-0276 |
| 通讯作者 | Zhu, xz() |
| 英文摘要 | We have recently studied several natural product constituents which have effects on the cns. (1) tetrahydropalmatine (thp) and its analogues were isolated from corydalis ambigua and various species of stephania. (+)-thp and (-)-thp possess not only analgesic activity, but also exert sedative-tranquilizing and hypnotic actions. results of receptor binding assay and their pre- and post-synaptic effects on dopaminergic system indicate that (-)-thp and (-)-stepholidine are dopamine receptor antagonists while (+)-thp is a selective dopamine depletor. (2) 3-acetylaconitine (aac) is an alkaloid isolated from aconitum flavum. the relative potency of analgesic action of aac was 5.1-35.6 and 1250-3912 times that of morphine and aspirin, respectively. the analgesic effect of aac was not antagonized by naloxone, but was eliminated by reserpine. in monkeys, after aac was injected for 92 days, no abstinence syndrome was seen after sudden aac withdrawal or when challenged with nalorphine. (3) huperzine a (hup-a) is an alkaloid isolated from huperzia serrata which was found to be a selective che inhibitor and could improve learning and retrieval processes. preliminary clinical studies showed that hup-a improve short- and long-term memory in patients of cerebral arteriosclerosis with memory impairment. (4) ranamargarin is a new tetradecapeptide isolated from the skin of the chinese frog rana margaratae. this peptide may mainly act on nk-1 receptor. |
| WOS关键词 | DISCRIMINATION PERFORMANCE ; HUPERZINE-A ; RATS ; 3-ACETYLACONITINE ; BRAIN |
| WOS研究方向 | Parasitology ; Tropical Medicine |
| WOS类目 | Parasitology ; Tropical Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991GN58900039 |
| 出版者 | MEM INST OSWALDO CRUZ |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373282 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | ZHU, XZ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHU, XZ. Development of natural-products as drugs acting on central-nervous-system[J]. Memorias do instituto oswaldo cruz,1991,86:173-175. |
| APA | ZHU, XZ.(1991).Development of natural-products as drugs acting on central-nervous-system.Memorias do instituto oswaldo cruz,86,173-175. |
| MLA | ZHU, XZ."Development of natural-products as drugs acting on central-nervous-system".Memorias do instituto oswaldo cruz 86(1991):173-175. |
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来源：武汉病毒研究所
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