Effect of n-omega-nitro-l-arginine on working-memory of rats in 8-arm maze task
文献类型：期刊论文
| 作者 | XIONG, ZQ; TANG, XC |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1995-07-01 |
| 卷号 | 16期号:4页码:301-304 |
| 关键词 | Memory Maze learning N-omega-nitro-l-arginine |
| ISSN号 | 0253-9756 |
| 英文摘要 | Aim: to study the effect of n omega omega-nitro-l-arginine (nna) (a no synthase inhibitor) on memory in the rats. methods: a delayed non-match-to-sample (dnmts) eight-arm maze task was used to study spatial working memory. results: intraperitoneal injection of nna 100 mg kg(-1) before the trial or at the start of the delay did not affect the accuracy, while pretraining administration of scopolamine 0.25 mg kg(-1) produced impairment in mnemonic performance as evidenced by fewer correct choices after the delay and more total errors to complete the task. intracerebroventricular infusion of nna (10, 50, 100 nmol) did not affect the accuracy. conclusion: a. single ip or icy injection of nna is not sufficient to alter the memory formation and use in this dnmts eight-arm maze task. |
| WOS关键词 | OXIDE SYNTHASE ; INHIBITION ; MESSENGER ; MICE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1995RJ09600004 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373283 |
| 专题 | 武汉病毒研究所 |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | XIONG, ZQ,TANG, XC. Effect of n-omega-nitro-l-arginine on working-memory of rats in 8-arm maze task[J]. Acta pharmacologica sinica,1995,16(4):301-304. |
| APA | XIONG, ZQ,&TANG, XC.(1995).Effect of n-omega-nitro-l-arginine on working-memory of rats in 8-arm maze task.Acta pharmacologica sinica,16(4),301-304. |
| MLA | XIONG, ZQ,et al."Effect of n-omega-nitro-l-arginine on working-memory of rats in 8-arm maze task".Acta pharmacologica sinica 16.4(1995):301-304. |
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来源：武汉病毒研究所
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