Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by a beta(25-35) in, hypercholesterolemic rats
文献类型：期刊论文
| 作者 | Ruan, Can-Jun1; Li, Zhan2,3; Zhang, Li4,5; Chen, Di-Hua2,3; Du, Guan-Hua4,5; Sun, Lan1 |
| 刊名 | Brain research bulletin
 |
| 出版日期 | 2010-07-30 |
| 卷号 | 82期号:5-6页码:251-258 |
| 关键词 | Alzheimer's disease Hypercholesterolemia Oxidative Stilbene Neuroprotective A beta(25-35) |
| ISSN号 | 0361-9230 |
| DOI | 10.1016/j.brainresbull.2010.04.016 |
| 通讯作者 | Ruan, can-jun(rcjjenny@msn.com) |
| 英文摘要 | Trans-2, 4-dimethoxystibene (s3) is a synthetic stilbenes. in the present study, 53 was investigated to assess its neuroprotective effect against the toxicity induced by a beta(25-35) in hypercholesterolemic rats. rats were fed with hypercholesterolemic chow for six weeks, and then received a single intracerebroventricular (icy.) injection of a beta(25-35) and a treatment with s3 or estradiol (e2). behavioral changes and neuron apoptosis in rats were evaluated using morris water maze, step-down test and tunel tests. to further explore the mechanism of s3, the activities of superoxide dismutase (sod), glutathione peroxidase (gsh-px), choline acetyl transferase (chat), acetylcholine esterase (ache) and the contents of malondialdehyde (mda) in hippocampus were analyzed by spectrophotometric method. at the same time, the releases of cytochrome c were analyzed by western blot, and the contents of acetylcholine (ach) were analyzed by elisa. the data showed that consumption of s3 (50 mg/kg/d) significantly ameliorated the cognitive deficits and neuron apoptosis caused by i.c.v, injection of a beta(25-35). meanwhile, s3 reversed the decreased activity of chat, sod, gsh-px and contents of ach, as well as the increased activity of ache, mda contents and the release of cytochrome c in hippocampus. these findings suggest that s3 may be a potential candidate for development as therapeutic agent to treat ad through regulating cholinergic nerve system and anti-oxidative mechanism. (c) 2010 elsevier inc. all rights reserved. |
| WOS关键词 | ALZHEIMERS-DISEASE BRAIN ; BETA-AMYLOID PEPTIDE ; OXIDATIVE STRESS ; TOTAL CHOLESTEROL ; APOLIPOPROTEIN-E ; SENILE PLAQUES ; IN-VITRO ; A-BETA ; PROTEIN ; DEMENTIA |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000281329500004 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373290 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ruan, Can-Jun |
| 作者单位 | 1.Chinese Acad Sci, Sch Basic Med, Peking Union Med Coll, Dept Pharmacol,Inst Basic Med Sci, Beijing 100005, Peoples R China 2.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100094, Peoples R China 3.Peking Union Med Coll, Beijing 100094, Peoples R China 4.Chinese Acad Med Sci, Inst Mat Med, Natl Ctr Pharmaceut Screening, Beijing 100050, Peoples R China 5.Peking Union Med Coll, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Can-Jun,Li, Zhan,Zhang, Li,et al. Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by a beta(25-35) in, hypercholesterolemic rats[J]. Brain research bulletin,2010,82(5-6):251-258. |
| APA | Ruan, Can-Jun,Li, Zhan,Zhang, Li,Chen, Di-Hua,Du, Guan-Hua,&Sun, Lan.(2010).Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by a beta(25-35) in, hypercholesterolemic rats.Brain research bulletin,82(5-6),251-258. |
| MLA | Ruan, Can-Jun,et al."Protective effects of trans-2, 4-dimethoxystibene on cognitive, impairments induced by a beta(25-35) in, hypercholesterolemic rats".Brain research bulletin 82.5-6(2010):251-258. |
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来源：武汉病毒研究所
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