Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | Acta pharmacologica sinica
 |
| 出版日期 | 1997-03-01 |
| 卷号 | 18期号:2页码:121-123 |
| 关键词 | Interleukin-6 Nitric oxide Avoidance learning Hippocampus Nitroprusside |
| ISSN号 | 0253-9756 |
| 通讯作者 | Ma, tc() |
| 英文摘要 | Aim: to study the effect of intrahippocampal infusion of interleukin-6 (il-6) on active avoidance in rats and the possible involvement of nitric oxide (no). methods: using a shuttle-box model, the effects of bilaterally intrahippocampal infusion of il-6 3.2, 16, and 80 ng as well as sodium nitroprusside (snp) 400 ng on active avoidance were studied on d 8 after administration. the levels of nitrite as an index of no in the hippocampus were detected using a fluorometric assay 24 h after infusion of il-6 3.2 or 80 ng. results: il-6 16 and 80 ng impaired the acquisition performance of active avoidance by prolonging the latency of avoidance in training, but not the retention performance in testing. ig-6 80 ng and snp 400 ng also resulted in a marked impairment in acquisition performances by decreasing the rate bf avoidance, but not in retention performances. il-6 80 ng markedly elevated the nitrite levels from 10.6 +/- 0.7 in control rats to 13,6 +/- 2.0 (nmol/g wet wt) (p < 0.01). il-6 3.2 ng had no effect on active avoidance nor on nitrite levels. conclusion: intrahippocampal infusion of il-6 impaired learning acquisition of active avoidance in rats. |
| WOS关键词 | HIPPOCAMPAL NITRIC-OXIDE ; MEMORY ; INHIBITION ; NO |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1997WM32200007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373298 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Ma, TC |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,DEPT PHARMACOL,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats[J]. Acta pharmacologica sinica,1997,18(2):121-123. |
| APA | Ma, TC,&Zhu, XZ.(1997).Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats.Acta pharmacologica sinica,18(2),121-123. |
| MLA | Ma, TC,et al."Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats".Acta pharmacologica sinica 18.2(1997):121-123. |
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来源：武汉病毒研究所
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