Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase
文献类型：期刊论文
| 作者 | Wu, Jiqin1,2; Gong, Peng1 |
| 刊名 | Viruses-basel
 |
| 出版日期 | 2018 |
| 卷号 | 10期号:1页码:7 |
| 关键词 | Rna viruses Rna-dependent rna polymerase Nucleotide addition cycle Active site closure Translocation |
| ISSN号 | 1999-4915 |
| DOI | 10.3390/v10010024 |
| 通讯作者 | Gong, peng(gongpeng@wh.iov.cn) |
| 英文摘要 | Viral rna-dependent rna polymerases (rdrps) are a class of nucleic acid polymerases bearing unique features from global architecture to catalytic mechanisms. in recent years, numerous viral rdrp crystal structures have improved the understanding of these molecular machines, in particular, for how they carry out each nucleotide addition cycle (nac) as directed by the rna template. this review focuses on a visual introduction of viral rdrp nac mechanisms through a combination of static pictures of structural models, a user-friendly software-based assembly of the structural models, and two videos illustrating key conformational changes in the nac. |
| WOS关键词 | STATE KINETIC-ANALYSIS ; STRUCTURAL BASIS ; RIBONUCLEOTIDE INCORPORATION ; CRYSTAL-STRUCTURE ; VIRUS POLYMERASE ; ACTIVE-SITE ; TRANSLOCATION ; CATALYSIS ; RNA-POLYMERASE-(3D(POL)) ; REPLICATION |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000424414900024 |
| 出版者 | MDPI AG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373310 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Gong, Peng |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jiqin,Gong, Peng. Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase[J]. Viruses-basel,2018,10(1):7. |
| APA | Wu, Jiqin,&Gong, Peng.(2018).Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase.Viruses-basel,10(1),7. |
| MLA | Wu, Jiqin,et al."Visualizing the nucleotide addition cycle of viral rna-dependent rna polymerase".Viruses-basel 10.1(2018):7. |
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来源：武汉病毒研究所
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