Longitudinal surveillance of betacoronaviruses in fruit bats in yunnan province, china during 2009-2016
文献类型：期刊论文
| 作者 | Luo, Yun1,5; Li, Bei1; Jiang, Ren-Di1; Hu, Bing-Jie1; Luo, Dong-Sheng1; Zhu, Guang-Jian2; Hu, Ben1; Liu, Hai-Zhou1; Zhang, Yun-Zhi3,4; Yang, Xing-Lou1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 33期号:1页码:87-95 |
| 关键词 | Betacoronavirus Surveillance Genetic diversity |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-018-0017-2 |
| 通讯作者 | Shi, zheng-li(zlshi@wh.iov.cn) |
| 英文摘要 | Previous studies indicated that fruit bats carry two betacoronaviruses, batcov hku9 and batcov gccdc1. to investigate the epidemiology and genetic diversity of these coronaviruses, we conducted a longitudinal surveillance in fruit bats in yunnan province, china during 2009-2016. a total of 59 (10.63%) bat samples were positive for the two betacorona-viruses, 46 (8.29%) for hku9 and 13 (2.34%) for gccdc1, or closely related viruses. we identified a novel hku9 strain, tentatively designated as batcov hku9-2202, by sequencing the full-length genome. the batcov hku9-2202 shared 83% nucleotide identity with other batcov hku9 stains based on whole genome sequences. the most divergent region is in the spike protein, which only shares 68% amino acid identity with batcov hku9. quantitative pcr revealed that the intestine was the primary infection organ of batcov hku9 and gccdc1, but some hku9 was also detected in the heart, kidney, and lung tissues of bats. this study highlights the importance of virus surveillance in natural reservoirs and emphasizes the need for preparedness against the potential spill-over of these viruses to local residents living near bat caves. |
| WOS关键词 | RESPIRATORY SYNDROME ; CORONAVIRUS ; VIRUSES ; ANTIBODIES ; ROUSETTUS ; SUBGROUP ; REVEALS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000428287700008 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373321 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zheng-Li |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 2.EcoHlth Alliance, New York, NY 10001 USA 3.Yunnan Inst Endem Dis Control & Prevent, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali 671000, Peoples R China 4.Dali Univ, Sch Publ Hlth, Dali 671000, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Yun,Li, Bei,Jiang, Ren-Di,et al. Longitudinal surveillance of betacoronaviruses in fruit bats in yunnan province, china during 2009-2016[J]. Virologica sinica,2018,33(1):87-95. |
| APA | Luo, Yun.,Li, Bei.,Jiang, Ren-Di.,Hu, Bing-Jie.,Luo, Dong-Sheng.,...&Shi, Zheng-Li.(2018).Longitudinal surveillance of betacoronaviruses in fruit bats in yunnan province, china during 2009-2016.Virologica sinica,33(1),87-95. |
| MLA | Luo, Yun,et al."Longitudinal surveillance of betacoronaviruses in fruit bats in yunnan province, china during 2009-2016".Virologica sinica 33.1(2018):87-95. |
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来源：武汉病毒研究所
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