Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c
文献类型：期刊论文
| 作者 | Wang, Bo1,4; Li, Wen1; Zhou, Ji-Hua2; Li, Bei1; Zhang, Wei1; Yang, Wei-Hong2; Pan, Hong2; Wang, Li-Xia3; Bock, C. Thomas4,5; Shi, Zheng-Li1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2018-02-01 |
| 卷号 | 33期号:1页码:44-58 |
| 关键词 | Hepatitis e virus (hev) Orthohepevirus Genetic diversity Complete genome Chevrier's field mouse Pere david's vole |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-018-0011-8 |
| 通讯作者 | Zhang, yun-zhi(zhangyunzhi1818@163.com) ; Yang, xing-lou(yangxl@wh.iov.cn) |
| 英文摘要 | Hepatitis e virus (hev) is the prototype of the family hepeviridae and the causative agent of common acute viral hepatitis. genetically diverse hev-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. in this study, we tested 278 specimens collected from seven wild small mammal species in yunnan province, china, for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription (rt)-pcr. hev-related sequences were detected in two rodent species, including chevrier's field mouse (apodemus chevrieri, family muridae) and psre david's vole (eothenomys melanogaster, family cricetidae), with the infection rates of 29.20% (59/202) and 7.27% (4/55), respectively. further four representative full-length genomes were generated: two each from chevrier's field mouse (named rdhevac14 and rdhevac86) and psre david's vole (rdhevem40 and rdhevem67). phylogenetic analyses and pairwise distance comparisons of whole genome sequences and amino acid sequences of the gene coding regions showed that orthohepeviruses identified in chinese chevrier's field mouse and psre david's vole belonged to the species orthohepevirus c but were highly divergent from the two assigned genotypes: hev-c1 derived from rat and shrew, and hev-c2 derived from ferret and possibly mink. quantitative real-time rt-pcr demonstrated that these newly discovered orthohepeviruses had hepatic tropism. in summary, our work discovered two putative novel genotypes orthohepeviruses preliminarily named hev-c3 and hev-c4 within the species orthohepevirus c, which expands our understanding of orthohepevirus infection in the order rodentia and gives new insights into the origin, evolution, and host range of orthohepevirus. |
| WOS关键词 | HEPATITIS-E VIRUS ; RATS RATTUS-NORVEGICUS ; UNITED-STATES ; WILD RATS ; FAMILY HEPEVIRIDAE ; CLASSIFICATION ; INFECTION ; CAMELS ; BATS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000428287700004 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373322 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhang, Yun-Zhi; Yang, Xing-Lou |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan 430070, Hubei, Peoples R China 2.Yunnan Inst Endem Dis Control & Prevent, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali 671000, Peoples R China 3.Dali Univ, Sch Publ Hlth, Dali 671000, Peoples R China 4.Robert Koch Inst, Dept Infect Dis, D-13353 Berlin, Germany 5.Univ Tubingen, Inst Trop Med, D-72076 Tubingen, Germany |
| 推荐引用方式 GB/T 7714 | Wang, Bo,Li, Wen,Zhou, Ji-Hua,et al. Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c[J]. Virologica sinica,2018,33(1):44-58. |
| APA | Wang, Bo.,Li, Wen.,Zhou, Ji-Hua.,Li, Bei.,Zhang, Wei.,...&Yang, Xing-Lou.(2018).Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c.Virologica sinica,33(1),44-58. |
| MLA | Wang, Bo,et al."Chevrier's field mouse (apodemus chevrieri) and psre david's vole (eothenomys melanogaster) in china carry orthohepeviruses that form two putative novel genotypes within the species orthohepevirus c".Virologica sinica 33.1(2018):44-58. |
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来源：武汉病毒研究所
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