Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection
文献类型：期刊论文
| 作者 | Qi, Mi1; Zhang, Xian-En2; Sun, Xianxun1; Zhang, Xiaowei1; Yao, Yanfeng3; Liu, Siling4; Chen, Ze5; Li, Wei1; Zhang, Zhiping1; Chen, Jianjun4 |
| 刊名 | Small
 |
| 出版日期 | 2018-03-27 |
| 卷号 | 14期号:13页码:9 |
| 关键词 | Ferritin Influenza Intranasal M2e Nanovaccines |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201703207 |
| 通讯作者 | Chen, jianjun(chenjj@wh.iov.cn) ; Cui, zongqiang(czq@wh.iov.cn) |
| 英文摘要 | Cross-protective and non-invasively administered vaccines are attractive and highly desired for the control of influenza. self-assembling nanotechnology provides an opportunity for the development of vaccines with superior performance. in this study, an intranasal nanovaccine is developed targeting the conserved ectodomain of influenza matrix protein 2(m2e). 3-sequential repeats of m2e (3m2e) is presented on the self-assembling recombinant human heavy chain ferritin (rhf) cage to form the 3m2e-rhf nanoparticle. intranasal vaccination with 3m2e-rhf nanoparticles in the absence of an adjuvant induces robust immune responses, including high titers of sera m2e-specific igg antibodies, t-cell immune responses, and mucosal secretory-iga antibodies in mice. the 3m2e-rhf nanoparticles also confer complete protection against a lethal infection of homo-subtypic h1n1 and hetero-subtypic h9n2 virus. an analysis of the mechanism of protection underlying the intranasal immunization with the 3m2e-rhf nanoparticle indicates that m2e-specific mucosal secretory-iga and t-cell immune responses may play critical roles in the prevention of infection. the results suggest that the 3m2e-rhf nanoparticle is a promising, needle-free, intranasally administered, cross-protective influenza vaccine. the use of self-assembling nanovaccines could be an ideal strategy for developing vaccines with characteristics such as high immunogenicity, cross-protection, and convenient administration, as well as being economical and suitable for large-scale production. |
| WOS关键词 | VIRUS-LIKE PARTICLES ; NANOPARTICLE VACCINES ; CROSS-PROTECTION ; MUCOSAL ; RESPONSES ; IMMUNITY ; PROTEIN ; VACCINATION ; ANTIGENS ; DELIVERY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000428797800002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373324 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Jianjun; Cui, Zongqiang |
| 作者单位 | 1.Univ Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 3.Wuhan Acad Agr Sci & Technol, Inst Anim Husb & Vet Sci, Wuhan 430208, Hubei, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 5.Hunan Normal Univ, Coll Life Sci, Changsha 410013, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Mi,Zhang, Xian-En,Sun, Xianxun,et al. Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection[J]. Small,2018,14(13):9. |
| APA | Qi, Mi.,Zhang, Xian-En.,Sun, Xianxun.,Zhang, Xiaowei.,Yao, Yanfeng.,...&Cui, Zongqiang.(2018).Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection.Small,14(13),9. |
| MLA | Qi, Mi,et al."Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection".Small 14.13(2018):9. |
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来源：武汉病毒研究所
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