Two genetically diverse h7n7 avian influenza viruses isolated from migratory birds in central china
文献类型：期刊论文
| 作者 | Liu, Haizhou1; Xiong, Chaochao1; Chen, Jing2; Chen, Guang2; Zhang, Jun2; Li, Yong2; Xiong, Yanping2; Wang, Runkun1; Cao, Ying1; Chen, Quanjiao1,3 |
| 刊名 | Emerging microbes & infections
 |
| 出版日期 | 2018-04-11 |
| 卷号 | 7页码:12 |
| ISSN号 | 2222-1751 |
| DOI | 10.1038/s41426-018-0064-7 |
| 通讯作者 | Chen, jianjun(chenjj@wh.iov.cn) |
| 英文摘要 | After the emergence of h7n9 avian influenza viruses (aiv) in early 2013 in china, active surveillance of aivs in migratory birds was undertaken, and two h7n7 strains were subsequently recovered from the fresh droppings of migratory birds; the strains were from different hosts and sampling sites. phylogenetic and sequence similarity network analyses indicated that several genes of the two h7n7 viruses were closely related to those in aivs circulating in domestic poultry, although different gene segments were implicated in the two isolates. this strongly suggested that genes from viruses infecting migratory birds have been introduced into poultry-infecting strains. a bayesian phylogenetic reconstruction of all eight segments implied that multiple reassortments have occurred in the evolution of these viruses, particularly during late 2011 and early 2014. antigenic analysis using a hemagglutination inhibition test showed that the two h7n7 viruses were moderately cross-reactive with h7n9-specific anti-serum. the ability of the two h7n7 viruses to remain infectious under various ph and temperature conditions was evaluated, and the viruses persisted the longest at near-neutral ph and in cold temperatures. animal infection experiments showed that the viruses were avirulent to mice and could not be recovered from any organs. our results indicate that low pathogenic, divergent h7n7 viruses circulate within the east asian-australasian flyway. virus dispersal between migratory birds and domestic poultry may increase the risk of the emergence of novel unprecedented strains. |
| WOS关键词 | CROSS-REACTIVE ANTIBODIES ; A VIRUSES ; HUMAN INFECTION ; WILD-BIRDS ; MOLECULAR-BASIS ; HOST-RANGE ; VACCINE ; PROTECTION ; ORIGIN ; WATER |
| WOS研究方向 | Immunology ; Microbiology |
| WOS类目 | Immunology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000430367300001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373330 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Jianjun |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 2.Res & Dev Ctr, Hubei Wildlife Rescue, Wuhan 430074, Hubei, Peoples R China 3.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 4.Univ Chinese Acad Sci, Beijing 101409, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Haizhou,Xiong, Chaochao,Chen, Jing,et al. Two genetically diverse h7n7 avian influenza viruses isolated from migratory birds in central china[J]. Emerging microbes & infections,2018,7:12. |
| APA | Liu, Haizhou.,Xiong, Chaochao.,Chen, Jing.,Chen, Guang.,Zhang, Jun.,...&Chen, Jianjun.(2018).Two genetically diverse h7n7 avian influenza viruses isolated from migratory birds in central china.Emerging microbes & infections,7,12. |
| MLA | Liu, Haizhou,et al."Two genetically diverse h7n7 avian influenza viruses isolated from migratory birds in central china".Emerging microbes & infections 7(2018):12. |
入库方式： iSwitch采集
来源：武汉病毒研究所
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