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Fatal swine acute diarrhoea syndrome caused by an hku2-related coronavirus of bat origin

文献类型：期刊论文

作者Zhou, Peng1; Fan, Hang2; Lan, Tian3,4; Yang, Xing-Lou1; Shi, Wei-Feng5; Zhang, Wei1; Zhu, Yan1; Zhang, Ya-Wei2; Xie, Qing-Mei3,4; Mani, Shailendra6
刊名Nature
出版日期2018-04-12
卷号556期号:7700页码:255-+
ISSN号0028-0836
DOI10.1038/s41586-018-0010-9
通讯作者Daszak, peter(daszak@ecohealthalliance.org) ; Wang, lin-fa(linfa.wang@duke-nus.edu.sg) ; Shi, zheng-li(zlshi@wh.iov.cn) ; Tong, yi-gang(tong.yigang@gmail.com) ; Ma, jing-yun(majy2400@scau.edu.cn)
英文摘要Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health(1). bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (sars)(2-10). here we provide virological, epidemiological, evolutionary and experimental evidence that a novel hku2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (sads-cov), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in china that has caused the death of 24,693 piglets across four farms. notably, the outbreak began in guangdong province in the vicinity of the origin of the sars pandemic. furthermore, we identified sads-related covs with 96-98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in guangdong province during 2013-2016, predominantly in horseshoe bats (rhinolophus spp.) that are known reservoirs of sars-related covs. we found that there were striking similarities between the sads and sars outbreaks in geographical, temporal, ecological and aetiological settings. this study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.
WOS关键词ACUTE RESPIRATORY SYNDROME ; CHINESE HORSESHOE BATS ; SARS-LIKE CORONAVIRUS ; FUNCTIONAL RECEPTOR ; SOUTHERN CHINA ; IDENTIFICATION ; SEQUENCE ; GENOME ; VIRUS
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000430082000050
URI标识http://www.irgrid.ac.cn/handle/1471x/2373333
专题武汉病毒研究所
通讯作者Daszak, Peter; Wang, Lin-Fa; Shi, Zheng-Li; Tong, Yi-Gang; Ma, Jing-Yun
作者单位1.Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China
2.Beijing Inst Microbiol & Epidemiol, Beijing, Peoples R China
3.South China Agr Univ, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
4.Key Lab Anim Hlth Aquaculture & Environm Control, Guangzhou, Guangdong, Peoples R China
5.Taishan Med Coll, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An, Shandong, Peoples R China
6.Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore
7.Guangdong Inst Appl Biol Resources, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangdong Key Lab Anim Conservat & Resource Util, Guangzhou, Guangdong, Peoples R China
8.Wuhan Univ, Sch Publ Hlth, Wuhan, Hubei, Peoples R China
9.Guangdong Lab Anim Monitoring Inst, Guangdong Key Lab Lab Anim, Guangzhou, Guangdong, Peoples R China
10.EcoHlth Alliance, New York, NY 10001 USA
推荐引用方式
GB/T 7714		 Zhou, Peng,Fan, Hang,Lan, Tian,et al. Fatal swine acute diarrhoea syndrome caused by an hku2-related coronavirus of bat origin[J]. Nature,2018,556(7700):255-+.
APA Zhou, Peng.,Fan, Hang.,Lan, Tian.,Yang, Xing-Lou.,Shi, Wei-Feng.,...&Ma, Jing-Yun.(2018).Fatal swine acute diarrhoea syndrome caused by an hku2-related coronavirus of bat origin.Nature,556(7700),255-+.
MLA Zhou, Peng,et al."Fatal swine acute diarrhoea syndrome caused by an hku2-related coronavirus of bat origin".Nature 556.7700(2018):255-+.

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来源：武汉病毒研究所

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