An excitatory neural assembly encodes short-term memory in the prefrontal cortex
文献类型：期刊论文
| 作者 | Tian, Yonglu1,2,3; Yang, Chaojuan1,2; Cui, Yaxuan1,2; Su, Feng1,2,4; Wang, Yongjie5,6,7,8; Wang, Yangzhen1,2,9; Yuan, Peijiang4; Shang, Shujiang1,2; Li, Hao10,11; Zhao, Jizong10,11 |
| 刊名 | Cell reports
 |
| 出版日期 | 2018-02-13 |
| 卷号 | 22期号:7页码:1734-1744 |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2018.01.050 |
| 通讯作者 | Qiu, zilong(zqiu@ion.ac.cn) ; Li, xiang-yao(lixiangy@zju.edu.cn) ; Zhang, chen(ch.zhang@pku.edu.cn) |
| 英文摘要 | Short-term memory (stm) is crucial for animals to hold information for a small period of time. persistent or recurrent neural activity, together with neural oscillations, is known to encode the stm at the cellular level. however, the coding mechanisms at the microcircuitry level remain a mystery. here, we performed two-photon imaging on behaving mice to monitor the activity of neuronal microcircuitry. we discovered a neuronal subpopulation in the medial prefrontal cortex (mpfc) that exhibited emergent properties in a context-dependent manner underlying a stm-like behavior paradigm. these neuronal subpopulations exclusively comprise excitatory neurons and mainly represent a group of neurons with stronger functional connections. microcircuitry plasticity was maintained for minutes and was absent in an animal model of alzheimer's disease (ad). thus, these results point to a functional coding mechanism that relies on the emergent behavior of a functionally defined neuronal assembly to encode stm. |
| WOS关键词 | FAMILIAL ALZHEIMERS-DISEASE ; WORKING-MEMORY ; SOMATOSENSORY CORTEX ; PERSISTENT ACTIVITY ; ENTORHINAL CORTEX ; PROTEIN-SYNTHESIS ; TRANSGENIC MICE ; SYNAPSE ; POTENTIATION ; PROBABILITY |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000424981600010 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373336 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Qiu, Zilong; Li, Xiang-Yao; Zhang, Chen |
| 作者单位 | 1.Peking Univ, Sch Life Sci, PKU IDG McGovern Inst Brain Res, State Key Lab Membrane Biol, Beijing 100191, Peoples R China 2.Peking Univ, Natl Hlth & Family Planning Commiss, Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China 4.Beihang Univ, Sch Mech Engn & Automat, Beijing 100191, Peoples R China 5.Xi An Jiao Tong Univ, Ctr Mitochondria Biol & Med, Xian 710049, Shaanxi, Peoples R China 6.Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Sch Life Sci & Technol, Minist Educ,Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China 7.Zhejiang Univ, Sch Med, Inst Neurosci, Dept Physiol, Hangzhou 310058, Zhejiang, Peoples R China 8.Zhejiang Univ, Sch Med, Collaborat Innovat Ctr Brain Sci, Hangzhou 310058, Zhejiang, Peoples R China 9.Tsinghua Univ, Sch Med, Sch Life Sci, Beijing 100084, Peoples R China 10.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Yonglu,Yang, Chaojuan,Cui, Yaxuan,et al. An excitatory neural assembly encodes short-term memory in the prefrontal cortex[J]. Cell reports,2018,22(7):1734-1744. |
| APA | Tian, Yonglu.,Yang, Chaojuan.,Cui, Yaxuan.,Su, Feng.,Wang, Yongjie.,...&Zhang, Chen.(2018).An excitatory neural assembly encodes short-term memory in the prefrontal cortex.Cell reports,22(7),1734-1744. |
| MLA | Tian, Yonglu,et al."An excitatory neural assembly encodes short-term memory in the prefrontal cortex".Cell reports 22.7(2018):1734-1744. |
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来源：武汉病毒研究所
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