Extensive evolution analysis of the global chikungunya virus strains revealed the origination of chikv epidemics in pakistan in 2016
文献类型：期刊论文
| 作者 | Shi, Junming1; Su, Zhengyuan1; Fan, Zhaojun1; Wang, Jun1; Liu, Siqing1; Zhang, Bo1; Wei, Hongping1; Jehan, Shoukat2; Jamil, Nadia2; Shen, Shu1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 32期号:6页码:520-532 |
| 关键词 | Chikungunya virus (chikv) Pakistan Phylogenetic analysis |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-017-4077-5 |
| 通讯作者 | Shen, shu(shenshu@wh.iov.cn) ; Deng, fei(df@wh.iov.cn) |
| 英文摘要 | Chikungunya virus (chikv) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. phylogenetic analysis has found that the chikv lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mosquito species and their distributions. in this study, we reported the complete genome sequences of eight chikv isolates from the outbreak in pakistan last year. then we reviewed the evolutionary history using extensive phylogenetic analysis, analyzed lineage-specific substitutions in viral proteins, and characterized the spreading pathway of chikv strains including the pakistani strains. the results showed that the pakistani stains belonged to the ecsa.iol sub-lineage and derived from india. the genetic properties of the pakistani strains including the adaptive substitution to vectors were further characterized, and the potential risks from the occurrence of chikv infection in pakistan were discussed. these results provided better understanding of chikv evolution and transmission in the world and revealed the possible origination of the chikv outbreak and epidemic in pakistan, which would promote the disease prevention and control in the identified countries and territories with the history of chikv infections as well as new regions with potential risk of chikv outbreaks. |
| WOS关键词 | INDIAN-OCEAN ; REEMERGENCE ; EMERGENCE ; OUTBREAK ; DISEASES ; TRACKING |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000419186700009 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373351 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shen, Shu; Deng, Fei |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Ctr Excellence Sci & Appl Technol, Islamabad 44000, Pakistan |
| 推荐引用方式 GB/T 7714 | Shi, Junming,Su, Zhengyuan,Fan, Zhaojun,et al. Extensive evolution analysis of the global chikungunya virus strains revealed the origination of chikv epidemics in pakistan in 2016[J]. Virologica sinica,2017,32(6):520-532. |
| APA | Shi, Junming.,Su, Zhengyuan.,Fan, Zhaojun.,Wang, Jun.,Liu, Siqing.,...&Deng, Fei.(2017).Extensive evolution analysis of the global chikungunya virus strains revealed the origination of chikv epidemics in pakistan in 2016.Virologica sinica,32(6),520-532. |
| MLA | Shi, Junming,et al."Extensive evolution analysis of the global chikungunya virus strains revealed the origination of chikv epidemics in pakistan in 2016".Virologica sinica 32.6(2017):520-532. |
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来源：武汉病毒研究所
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