Dc-sign promotes japanese encephalitis virus transmission from dendritic cells to t cells via virological synapses
文献类型：期刊论文
| 作者 | Wang, Ping1,2; Li, Mei1,2; Lu, Wei4; Zhang, Di1,2; Hu, Qinxue1,3; Liu, Yalan1 |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 32期号:6页码:495-502 |
| ISSN号 | 1674-0769 |
| 关键词 | Japanese encephalitis virus (jev) Dc-sign T lymphocytes In trans |
| DOI | 10.1007/s12250-017-4034-3 |
| 通讯作者 | Hu, qinxue(qhu@wh.iov.cn) ; Liu, yalan(liuyl@wh.iov.cn) |
| 英文摘要 | Skin-resident dendritic cells (dcs) likely encounter incoming viruses in the first place, and their migration to lymph nodes following virus capture may promote viral replication. however, the molecular mechanisms underlying these processes remain unclear. in the present study, we found that compared to cell-free viruses, dc-bound viruses showed enhanced capture of jev by t cells. additionally, jev infection was increased by co-culturing dcs and t cells. blocking the c-type lectin receptor dc-specific intercellular adhesion molecule-3-grabbing non-integrin (dc-sign) with neutralizing antibodies or antagonists blocked jev transmission to t cells. live-cell imaging revealed that dcs captured and transferred jev viral particles to t cells via virological synapses formed at dc-t cell junctions. these findings indicate that dc-sign plays an important role in jev transmission from dcs to t cells and provide insight into how jev exploits the migratory and antigen-presenting capabilities of dcs to gain access to lymph nodes for dissemination and persistence in the host. |
| WOS关键词 | IMMUNE-RESPONSES ; TRANS-INFECTION ; HIV-1 ; LATENCY ; LYMPHOCYTES ; MACROPHAGES ; BINDING |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000419186700006 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373353 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Hu, Qinxue; Liu, Yalan |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England 4.Huazhong Univ Sci & Technol, Yuhan Childrens Hosp, Tongji Med Coll, Wuhan Maternal & Child Healthcare Hosp, Wuhan 430016, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ping,Li, Mei,Lu, Wei,et al. Dc-sign promotes japanese encephalitis virus transmission from dendritic cells to t cells via virological synapses[J]. Virologica sinica,2017,32(6):495-502. |
| APA | Wang, Ping,Li, Mei,Lu, Wei,Zhang, Di,Hu, Qinxue,&Liu, Yalan.(2017).Dc-sign promotes japanese encephalitis virus transmission from dendritic cells to t cells via virological synapses.Virologica sinica,32(6),495-502. |
| MLA | Wang, Ping,et al."Dc-sign promotes japanese encephalitis virus transmission from dendritic cells to t cells via virological synapses".Virologica sinica 32.6(2017):495-502. |
入库方式： iSwitch采集
来源：武汉病毒研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。