Expression pattern of individual ifna subtypes in chronic hiv infection
文献类型：期刊论文
| 作者 | Li, Yanpeng1; Sun, Binlian1; Esser, Stefan2; Jessen, Heiko3; Streeck, Hendrik4; Widera, Marek5; Yang, Rongge1; Dittmer, Ulf5; Sutter, Kathrin5 |
| 刊名 | Journal of interferon and cytokine research
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 37期号:12页码:541-549 |
| 关键词 | Ifn-alpha subtypes Isg expression Ifn-alpha stimulation Chronic hiv infection |
| ISSN号 | 1079-9907 |
| DOI | 10.1089/jir.2017.0076 |
| 通讯作者 | Sutter, kathrin(kathrin.sutter@uni-due.de) |
| 英文摘要 | Interferon- (ifn-) plays an important role in hiv pathogenesis. ifn- consists of 13 individual ifn- subtypes, which exhibit individual antiviral and immunomodulatory activities in hiv infection. here, we determined the expression profiles of all ifn- subtypes in treated and treatment-naive hiv+ patients and their impact on the induction of distinct hiv restriction factors. we collected blood samples of chronic hiv+ patients, which underwent antiretroviral therapy or were treatment-naive, and determined the individual expression levels of different ifn- subtypes and hiv restriction factors. hiv infection transiently enhanced the expression of ifna mrna. the ifn- response was dominated by the most abundantly expressed subtypes ifna4, a5, a7, and a14 in all individuals. hiv infection affected the expression pattern of the ifn- response, in particular for ifna2 and ifna16, which were elevated by chronic hiv infection. elevated expression of hiv restriction factors was observed in chronically hiv-infected patients, which partly decreased during successful antiretroviral treatment. in vitro stimulation of peripheral blood mononuclear cells revealed that ifn-6, -14, and -21 were most effective in inducing the expression of hiv restriction factors. these results indicate that hiv infection induces a specific expression pattern of ifn- subtypes, which in turn induce the expression of various hiv restriction factors. |
| WOS关键词 | PERSISTENT LCMV INFECTION ; VIRUS TYPE-1 INFECTION ; HUMAN ALPHA-INTERFERON ; INHIBITS HIV-1 ; IN-VIVO ; DISEASE PROGRESSION ; VIRAL-INFECTION ; SOOTY MANGABEYS ; SIV INFECTION ; HEPATITIS-B |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology ; Immunology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology ; Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000418243300004 |
| 出版者 | MARY ANN LIEBERT, INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373355 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Sutter, Kathrin |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 2.Univ Duisburg Essen, Univ Hosp Essen, Dermatol Clin, Essen, Germany 3.HIV Clin Praxis, Berlin, Germany 4.Univ Duisburg Essen, Univ Hosp Essen, Inst HIV Res, Essen, Germany 5.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45147 Essen, Germany |
| 推荐引用方式 GB/T 7714 | Li, Yanpeng,Sun, Binlian,Esser, Stefan,et al. Expression pattern of individual ifna subtypes in chronic hiv infection[J]. Journal of interferon and cytokine research,2017,37(12):541-549. |
| APA | Li, Yanpeng.,Sun, Binlian.,Esser, Stefan.,Jessen, Heiko.,Streeck, Hendrik.,...&Sutter, Kathrin.(2017).Expression pattern of individual ifna subtypes in chronic hiv infection.Journal of interferon and cytokine research,37(12),541-549. |
| MLA | Li, Yanpeng,et al."Expression pattern of individual ifna subtypes in chronic hiv infection".Journal of interferon and cytokine research 37.12(2017):541-549. |
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来源：武汉病毒研究所
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