Zikv infection effects changes in gene splicing, isoform composition and lncrna expression in human neural progenitor cells
文献类型：期刊论文
| 作者 | Hu, Benxia1,2; Huo, Yongxia1; Yang, Liping1; Chen, Guijun1; Luo, Minhua3; Yang, Jinlong4,5; Zhou, Jumin1 |
| 刊名 | Virology journal
 |
| 出版日期 | 2017-11-07 |
| 卷号 | 14页码:11 |
| 关键词 | Lncrna Gene isoform Alternative splicing Hnpc Zikv |
| ISSN号 | 1743-422X |
| DOI | 10.1186/s12985-017-0882-6 |
| 通讯作者 | Zhou, jumin(zhoujm@mail.kiz.ac.cn) |
| 英文摘要 | Background: the zika virus (zikv) is a mosquito-borne flavivirus that causes microcephaly and guillain-barre syndrome in infected individuals. to obtain insights into the mechanism of zikv infection and pathogenesis, we analyzed the transcriptome of zikv infected human neural progenitor cells (hnpcs) for changes in alternative splicing (as), gene isoform (iso) composition and long noncoding rnas (lncrnas) expression. methods: we analyzed differentially expressed lncrnas, as, iso from rna-seq data in zikv infected hnpcs. results: we obtained 149 differentially expressed lncrnas, including potential viral targets to modulate cellular processes such as cell cycle, apoptosis and immune response. the infection induced 262 cases of as occurring in 229 genes, which were enriched in cell death, rna processing, transport, and neuron development. among 691 differentially expressed isos, upregulated isos were enriched in signaling, regulation of transcription, and amino acid biosynthesis, while downregulated isos were mostly enriched in cell cycle. importantly, these analyses revealed specific links between zikv induced changes in cellular pathways and the type of changes in the host transcriptome, suggesting important regulatory mechanisms. conclusions: our analyses revealed candidate lncrnas, as events and isos which may function in zikv infection induced cell cycle disruption, apoptosis and attenuation of neurogenesis, and shed light on the roles of lncrnas, as and isos in virus-host interactions, and would facilitate future studies of zikv infection and pathogenesis. |
| WOS关键词 | RNA-SEQ ; VIRUS ; REVEALS ; CANCER ; FAMILY ; ACTIVATION ; MECHANISM ; PROFILES ; PROTEINS ; DISEASE |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000414785200001 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373361 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Zhou, Jumin |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Bioact Peptides Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China 3.Wuhan Inst Virol, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 4.BGI Shenzhen, BGI Yunnan, Kunming 650000, Yunnan, Peoples R China 5.Yunnan Univ, Coll Life Sci, Kunming 650091, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Benxia,Huo, Yongxia,Yang, Liping,et al. Zikv infection effects changes in gene splicing, isoform composition and lncrna expression in human neural progenitor cells[J]. Virology journal,2017,14:11. |
| APA | Hu, Benxia.,Huo, Yongxia.,Yang, Liping.,Chen, Guijun.,Luo, Minhua.,...&Zhou, Jumin.(2017).Zikv infection effects changes in gene splicing, isoform composition and lncrna expression in human neural progenitor cells.Virology journal,14,11. |
| MLA | Hu, Benxia,et al."Zikv infection effects changes in gene splicing, isoform composition and lncrna expression in human neural progenitor cells".Virology journal 14(2017):11. |
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来源：武汉病毒研究所
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