Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses
文献类型：期刊论文
| 作者 | Luo, Wei-Wei1; Shu, Hong-Bing2 |
| 刊名 | Febs letters
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 591期号:20页码:3182-3189 |
| 关键词 | Inflammatory responses Innate immunity Rhomboid-like pseudoprotease |
| ISSN号 | 1873-3468 |
| DOI | 10.1002/1873-3468.12796 |
| 通讯作者 | Shu, hong-bing(shuh@whu.edu.cn) |
| 英文摘要 | Rhomboid-like pseudoproteases are a conserved superfamily of proteins related to the rhomboid intramembrane serine proteases that lack key catalytic residues. irhom2, a member of the rhomboid-like pseudoprotease superfamily, regulates the maturation and trafficking of adam17 and is associated with inflammatory arthritis. recent studies demonstrate that irhom2 is also involved in innate immunity by regulating the trafficking and stability of mita (also called sting), which is a central adaptor in innate antiviral signalling pathways. here, we summarize recent progress on the roles and mechanisms of irhom2 and its homologues in innate immunity and also discuss the links between the physiological functions of irhoms and immunological diseases. |
| WOS关键词 | NECROSIS-FACTOR-ALPHA ; INTRAMEMBRANE SERINE PROTEASES ; MEMBRANE-PROTEIN ; ENDOPLASMIC-RETICULUM ; RHEUMATOID-ARTHRITIS ; FAMILY PROTEINS ; QUALITY-CONTROL ; TNF-ALPHA ; ACTIVATION ; IRHOM2 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000413767100003 |
| 出版者 | WILEY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373362 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shu, Hong-Bing |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China 2.Wuhan Univ, Sch Med, Med Res Inst, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Wei-Wei,Shu, Hong-Bing. Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses[J]. Febs letters,2017,591(20):3182-3189. |
| APA | Luo, Wei-Wei,&Shu, Hong-Bing.(2017).Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses.Febs letters,591(20),3182-3189. |
| MLA | Luo, Wei-Wei,et al."Emerging roles of rhomboid-like pseudoproteases in inflammatory and innate immune responses".Febs letters 591.20(2017):3182-3189. |
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来源：武汉病毒研究所
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