The ser/thr protein kinase protein-protein interaction map of m-tuberculosis
文献类型：期刊论文
| 作者 | Wu, Fan-Lin1,2; Liu, Yin1,2; Jiang, He-Wei1,2; Luan, Yi-Zhao3; Zhang, Hai-Nan1,2; He, Xiang1,2,4; Xu, Zhao-Wei1,2; Hou, Jing-Li5; Ji, Li-Yun1; Xie, Zhi3 |
| 刊名 | Molecular & cellular proteomics
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 16期号:8页码:1491-1506 |
| ISSN号 | 1535-9476 |
| DOI | 10.1074/mcp.m116.065771 |
| 通讯作者 | Tao, sheng-ce(taosc@sjtu.edu.cn) |
| 英文摘要 | Mycobacterium tuberculosis (mtb) is the causative agent of tuberculosis, the leading cause of death among all infectious diseases. there are 11 eukaryotic-like serine/threonine protein kinases (stpks) in mtb, which are thought to play pivotal roles in cell growth, signal transduction and pathogenesis. however, their underlying mechanisms of action remain largely uncharacterized. in this study, using a mtb proteome microarray, we have globally identified the binding proteins in mtb for all of the stpks, and constructed the first stpk protein interaction (kpi) map that includes 492 binding proteins and 1,027 interactions. bioinformatics analysis showed that the interacting proteins reflect diverse functions, including roles in two-component system, transcription, protein degradation, and cell wall integrity. functional investigations confirmed that pkng regulates cell wall integrity through key components of peptidoglycan (pg) biosynthesis, e.g. murc. the global stpk-kpis network constructed here is expected to serve as a rich resource for understanding the key signaling pathways in mtb, thus facilitating drug development and effective control of mtb. |
| WOS关键词 | CELL-WALL SYNTHESIS ; PEPTIDOGLYCAN BIOSYNTHESIS ; ANALYSIS REVEALS ; GLOBAL ANALYSIS ; PHOSPHORYLATION ; IDENTIFICATION ; NETWORKS ; WAG31 ; YEAST ; PKNA |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemical Research Methods |
| 语种 | 英语 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| WOS记录号 | WOS:000406638100007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373364 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Tao, Sheng-Ce |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Minist Educ, Key Lab Syst Biomed, 800 Dongchuan Rd, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Shanghai 200240, Peoples R China 3.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, Guangdong Prov Key Lab Ophthalmol & Visual Sci, State Key Lab Ophthalmol, Guangzhou 500040, Guangdong, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China 5.Shanghai Jiao Tong Univ, Instrumental Anal Ctr, Shanghai 200240, Peoples R China 6.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 7.Chinese Acad Sci, Inst Biophys, Natl Key Lab Biomacromol, Key Lab Noncoding RNA, Beijing 100101, Peoples R China 8.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China 9.Foshan Univ, Sch Stomatol & Med, Foshan 528000, Guangdong, Peoples R China 10.Guangdong Prov Key Lab TB Syst Biol & Translat Me, Foshan 528000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Fan-Lin,Liu, Yin,Jiang, He-Wei,et al. The ser/thr protein kinase protein-protein interaction map of m-tuberculosis[J]. Molecular & cellular proteomics,2017,16(8):1491-1506. |
| APA | Wu, Fan-Lin.,Liu, Yin.,Jiang, He-Wei.,Luan, Yi-Zhao.,Zhang, Hai-Nan.,...&Tao, Sheng-Ce.(2017).The ser/thr protein kinase protein-protein interaction map of m-tuberculosis.Molecular & cellular proteomics,16(8),1491-1506. |
| MLA | Wu, Fan-Lin,et al."The ser/thr protein kinase protein-protein interaction map of m-tuberculosis".Molecular & cellular proteomics 16.8(2017):1491-1506. |
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来源：武汉病毒研究所
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