Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in china
文献类型：期刊论文
| 作者 | Zhang, Xiaowei1; Qin, Chong1; Li, Wei1; Zhene, Zhenhua1,2; Wang, Hanzhong1,2; Cui, Zongqiang1 |
| 刊名 | Virus research
 |
| 出版日期 | 2017-06-15 |
| 卷号 | 238页码:179-182 |
| 关键词 | Vdpvs Highly divergent Reversion mutations China |
| ISSN号 | 0168-1702 |
| DOI | 10.1016/j.virusres.2017.06.017 |
| 通讯作者 | Cui, zongqiang(czq@wh.iov.cn) |
| 英文摘要 | In this study, we report the identification and characterization of a highly evolved type 3 vaccine-derived poliovirus (vdpv) strain designated as wiv14, isolated in 2014 from a 4-year-old child suspected of having an enteroviral infection in china. complete genome sequence of wiv14 revealed multiple nucleotide substitutions when compared with the attenuated poliovirus (pv) sabin 3, including the reversion of three major attenuation sites to wild type. from the nucleotide divergence for the p1/capsid region, we estimated that the evolution time of wiv14 was more than 7 years, indicating the possible long time of replication. wiv14 strain seemed to have differences in biological characteristics compared with attenuated pv strains, such as being non-temperature sensitive and producing large plaques. the current isolation of a highly divergent type 3 vdpv gives an idea of the risk of emergent vdpv strains, and emphasizes the importance of maintaining high vaccination coverage and herd immunity against pvs in china. |
| WOS关键词 | COMPREHENSIVE ANALYSIS ; RECOMBINANT SEQUENCES ; DEOXYINOSINE RESIDUES ; CODON DEGENERACY ; MOSAIC STRUCTURE ; MIXED-BASE ; IDENTIFICATION ; PRIMERS ; ERADICATION ; POSITIONS |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000408077500024 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373382 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Cui, Zongqiang |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Xiaohongshan 44, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaowei,Qin, Chong,Li, Wei,et al. Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in china[J]. Virus research,2017,238:179-182. |
| APA | Zhang, Xiaowei,Qin, Chong,Li, Wei,Zhene, Zhenhua,Wang, Hanzhong,&Cui, Zongqiang.(2017).Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in china.Virus research,238,179-182. |
| MLA | Zhang, Xiaowei,et al."Isolation and characterization of a highly evolved type 3 vaccine-derived poliovirus in china".Virus research 238(2017):179-182. |
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来源：武汉病毒研究所
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