Identification of novel long non-coding and circular rnas in human papillomavirus-mediated cervical cancer
文献类型：期刊论文
| 作者 | Wang, Hongbo1; Zhao, Yingchao2; Chen, Mingyue3; Cui, Jie3 |
| 刊名 | Frontiers in microbiology
 |
| 出版日期 | 2017-09-19 |
| 卷号 | 8页码:12 |
| 关键词 | Cervical cancer Rna-seq Lncrnas Circrnas Cerna Hpv |
| ISSN号 | 1664-302X |
| DOI | 10.3389/fmicb.2017.01720 |
| 通讯作者 | Chen, mingyue(chmy@wh.iov.cn) ; Cui, jie(jiecui@wh.iov.cn) |
| 英文摘要 | Cervical cancer is the third most common cancer worldwide and the fourth leading cause of cancer-associated mortality in women. accumulating evidence indicates that long non-coding rnas (lncrnas) and circular rnas (circrnas) may play key roles in the carcinogenesis of different cancers; however, little is known about the mechanisms of lncrnas and circrnas in the progression and metastasis of cervical cancer. in this study, we explored the expression profiles of lncrnas, circrnas, mirnas, and mrnas in hpv16 (human papillomavirus genotype 16) mediated cervical squamous cell carcinoma and matched adjacent non-tumor (atn) tissues from three patients with high-throughput rna sequencing (rna-seq). in total, we identified 19 lncrnas, 99 circrnas, 28 mirnas, and 304 mrnas that were commonly differentially expressed (de) in different patients. among the non-coding rnas, 3 lncrnas and 44 circrnas are novel to our knowledge. functional enrichment analysis showed that de lncrnas, mirnas, and mrnas were enriched in pathways crucial to cancer as well as other gene ontology (go) terms. furthermore, the co-expression network and function prediction suggested that all 19 de lncrnas could play different roles in the carcinogenesis and development of cervical cancer. the competing endogenous rna (cerna) network based on de coding and non-coding rnas showed that each mirna targeted a number of lncrnas and circrnas. the link between part of the mirnas in the network and cervical cancer has been validated in previous studies, and these mirnas targeted the majority of the novel non-coding rnas, thus suggesting that these novel non-coding rnas may be involved in cervical cancer. taken together, our study shows that de non-coding rnas could be further developed as diagnostic and therapeutic biomarkers of cervical cancer. the complex cerna network also lays the foundation for future research of the roles of coding and non-coding rnas in cervical cancer. |
| WOS关键词 | POTENTIAL BIOMARKERS ; CELL-PROLIFERATION ; POOLED ANALYSIS ; BREAST-CANCER ; SEQ DATA ; GENE ; EXPRESSION ; GROWTH ; DICKKOPF-1 ; RESISTANCE |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000411070500001 |
| 出版者 | FRONTIERS MEDIA SA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373389 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Mingyue; Cui, Jie |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Obstet & Gynecol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Canc Ctr, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Special Pathogens & Biosafety, Ctr Emerging Infect Dis, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hongbo,Zhao, Yingchao,Chen, Mingyue,et al. Identification of novel long non-coding and circular rnas in human papillomavirus-mediated cervical cancer[J]. Frontiers in microbiology,2017,8:12. |
| APA | Wang, Hongbo,Zhao, Yingchao,Chen, Mingyue,&Cui, Jie.(2017).Identification of novel long non-coding and circular rnas in human papillomavirus-mediated cervical cancer.Frontiers in microbiology,8,12. |
| MLA | Wang, Hongbo,et al."Identification of novel long non-coding and circular rnas in human papillomavirus-mediated cervical cancer".Frontiers in microbiology 8(2017):12. |
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来源：武汉病毒研究所
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