The process of wrapping virus revealed by a force tracing technique and simulations
文献类型：期刊论文
| 作者 | Pan, Yangang1; Zhang, Fuxian2; Zhang, Liuyang3; Liu, Shuheng1; Cai, Mingjun1; Shan, Yuping1,4; Wang, Xianqiao3; Wang, Hanzhong2,5; Wang, Hongda1,5 |
| 刊名 | Advanced science
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 4期号:9页码:7 |
| 关键词 | Force tracing Hev71 Internalization Single particle simulation Wrapped |
| ISSN号 | 2198-3844 |
| DOI | 10.1002/advs.201600489 |
| 通讯作者 | Shan, yuping(shanyp@ciac.ac.cn) ; Wang, xianqiao(xqwang@uga.edu) ; Wang, hanzhong(wanghz@wh.iov.cn) ; Wang, hongda(hdwang@ciac.ac.cn) |
| 英文摘要 | Viral entry into the host cell is the first step of virus infection; however, its dynamic process via endocytosis remains largely elusive. here, the force tracing technique and single particle simulation are combined to investigate the invagination of single human enterovirus 71 (hev71, a positive single-stranded rna virus that is associated with hand, foot, and mouth disease) via cell membranes during its host cell entry. the experimental results reveal that the hev71 invaginates in membrane vesicles at a force of 58 +/- 16 pn, a duration time of 278 +/- 68 ms. the simulation further shows that the virus can reach a partially wrapped state very fast, then the upper surface of the virus is covered by the membrane traveling over a long period of time. combining the experiment with the simulation, the mechanism of membrane wrapping of virus is uncovered, which provides new insights into how the cell is operated to initiate the endocytosis of virus. |
| WOS关键词 | RECEPTOR-MEDIATED ENDOCYTOSIS ; INDIVIDUAL INFLUENZA-VIRUSES ; SINGLE GOLD NANOPARTICLES ; ENTEROVIRUS 71 ; PARTICLES ; INFECTION ; MICROSCOPY ; GENERATION ; PATHWAY ; CELLS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000411148100006 |
| 出版者 | WILEY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373391 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shan, Yuping; Wang, Xianqiao; Wang, Hanzhong; Wang, Hongda |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Electroanalyt Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Hubei, Peoples R China 3.Univ Georgia, Coll Engn, Athens, GA 30602 USA 4.Changchun Univ Technol, Adv Inst Mat Sci, Sch Chem & Life Sci, Changchun 130012, Jilin, Peoples R China 5.Univ Chinese Acad Sci, State Key Lab Electroanalyt Chem, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Yangang,Zhang, Fuxian,Zhang, Liuyang,et al. The process of wrapping virus revealed by a force tracing technique and simulations[J]. Advanced science,2017,4(9):7. |
| APA | Pan, Yangang.,Zhang, Fuxian.,Zhang, Liuyang.,Liu, Shuheng.,Cai, Mingjun.,...&Wang, Hongda.(2017).The process of wrapping virus revealed by a force tracing technique and simulations.Advanced science,4(9),7. |
| MLA | Pan, Yangang,et al."The process of wrapping virus revealed by a force tracing technique and simulations".Advanced science 4.9(2017):7. |
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来源：武汉病毒研究所
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