Interaction between herpesvirus entry mediator and hsv-2 glycoproteins mediates hiv-1 entry of hsv-2-infected epithelial cells
文献类型：期刊论文
| 作者 | Hu, Kai1,2; He, Siyi1; Xiao, Juhua3; Li, Mei1; Luo, Sukun4; Zhang, Mudan1; Hu, Qinxue1,2 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 98期号:9页码:2351-2361 |
| 关键词 | Hiv-1 Hsv-2 Herpesvirus entry mediator Co-infection |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/jgv.0.000895 |
| 通讯作者 | Hu, kai(huk@wh.iov.cn) ; Hu, qinxue(qhu@wh.iov.cn) |
| 英文摘要 | Herpes simplex virus type 2 (hsv-2) increases human immunodeficiency virus type 1 (hiv-1) acquisition and transmission via unclear mechanisms. herpesvirus entry mediator (hvem), an hsv-2 entry receptor, is highly expressed on hiv-1 target cells (cd4(+) t cells) and may be incorporated into hiv-1 virions, while hsv-2 glycoproteins can be present on the infected cell surface. since hvem-gd interaction together with gb/gh/gl is essential for hsv-2 entry, hvem-bearing hiv-1 (hiv-1/hvem) may enter hsv-2-infected cells through such interactions. to test this hypothesis, we first confirmed the presence of hvem on hiv-1 virions and glycoproteins on the hsv-2-infected cell surface. additional studies showed that hiv-1/hvem bound to the hsv-2-infected cell surface in an hsv-2 infection-time-dependent manner via hvem-gd interaction. hiv-1/hvem entry of hsv-2-infected cells was dependent on hvem-gd interaction and the presence of gb/gh/gl, and was inhibited by azidothymidine. furthermore, peripheral blood mononuclear cell-derived hiv-1 infected hsv-2-infected primary foreskin epithelial cells and the infection was inhibited by anti-hvem/gd antibodies. together, our results indicate that hiv-1 produced from cd4(+) t cells bears hsv-2 receptor hvem and can bind to and enter hsv-2-infected epithelial cells depending on hvem-gd interaction and the presence of gb/gh/gl. our findings provide a potential new mechanism underlying hsv-2 infection-enhanced hiv-1 mucosal transmission and may shed light on hiv-1 prevention. |
| WOS关键词 | IMMUNODEFICIENCY-VIRUS TYPE-1 ; SIMPLEX-VIRUS ; HOST PROTEINS ; VIRAL ENTRY ; T-CELLS ; INFECTION ; FUSION ; ACQUISITION ; TRANSMISSION ; RECOMBINANTS |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000411713000015 |
| 出版者 | MICROBIOLOGY SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373392 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Hu, Kai; Hu, Qinxue |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England 3.Jiangxi Prov Maternal & Child Hlth Hosp, Dept Ultrasound, Nanchang 330006, Jiangxi, Peoples R China 4.Wuhan Med & Healthcare Ctr Women & Children, Clin Res Ctr, Wuhan 430016, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Kai,He, Siyi,Xiao, Juhua,et al. Interaction between herpesvirus entry mediator and hsv-2 glycoproteins mediates hiv-1 entry of hsv-2-infected epithelial cells[J]. Journal of general virology,2017,98(9):2351-2361. |
| APA | Hu, Kai.,He, Siyi.,Xiao, Juhua.,Li, Mei.,Luo, Sukun.,...&Hu, Qinxue.(2017).Interaction between herpesvirus entry mediator and hsv-2 glycoproteins mediates hiv-1 entry of hsv-2-infected epithelial cells.Journal of general virology,98(9),2351-2361. |
| MLA | Hu, Kai,et al."Interaction between herpesvirus entry mediator and hsv-2 glycoproteins mediates hiv-1 entry of hsv-2-infected epithelial cells".Journal of general virology 98.9(2017):2351-2361. |
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来源：武汉病毒研究所
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