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Bap180/baf180 is required to maintain homeostasis of intestinal innate immune response in drosophila and mice

文献类型：期刊论文

作者He, Xiaomeng1; Yu, Junjing1; Wang, Min2; Cheng, Yang3; Han, Yanan2; Yang, Shuo1,4; Shi, Guizhi4,5; Sun, Lei5; Fang, Ying2; Gong, Si-tang3
刊名Nature microbiology
出版日期2017-06-01
卷号2期号:6页码:13
ISSN号2058-5276
DOI10.1038/nmicrobiol.2017.56
通讯作者Pan, lei(panlei@moon.ibp.ac.cn) ; Tang, hong(htang@ips.ac.cn)
英文摘要Immune homeostasis is a prerequisite to protective immunity against gastrointestinal infections. in drosophila, immune deficiency (imd) signalling (tumour necrosis factor receptor/interleukin-1 receptor, tnfr/il-1r in mammals) is indispensable for intestinal immunity against invading bacteria. however, how this local antimicrobial immune response contributes to inflammatory regulation remains poorly defined. here, we show that flies lacking intestinal bap180 (a subunit of the chromatin-remodelling switch/sucrose non-fermentable (swi/snf)complex) are susceptible to infection as a result of hyper-inflammation rather than bacterial overload. detailed analysis shows that bap180 is induced by the imd-relish response to both enteropathogenic and commensal bacteria. upregulated bap180 can feed back to restrain overreactive imd signalling, as well as to repress the expression of the pro-inflammatory gene eiger (tnf), a critical step to prevent excessive tissue damage and elongate the lifespan of flies, under pathological and physiological conditions, respectively. furthermore, intestinal targeting of baf180 renders mice susceptible to a more aggressive infectious colitis caused by citrobacter rodentium. together, bap180 and baf180 serve as a conserved transcriptional repressor that is critical for the maintenance of innate immune homeostasis in the intestines.
WOS关键词GUT IMMUNITY ; PEPTIDOGLYCAN RECOGNITION ; HOST-DEFENSE ; PGRP-LC ; PATHWAY ; PROTEIN ; MELANOGASTER ; COMPLEX ; DEATH ; EXPRESSION
WOS研究方向Microbiology
WOS类目Microbiology
语种英语
WOS记录号WOS:000406000900014
出版者NATURE PUBLISHING GROUP
URI标识http://www.irgrid.ac.cn/handle/1471x/2373411
专题武汉病毒研究所
通讯作者Pan, Lei; Tang, Hong
作者单位1.Inst Biophys, CASKLII, Beijing 100101, Peoples R China
2.Xian Childrens Hosp, Dept Gastroenterol, Xian 710006, Peoples R China
3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou 510000, Guangdong, Peoples R China
4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
5.Inst Biophys, Core Facil Prot Res, Beijing 100101, Peoples R China
6.Univ Michigan, Dept Cardiac Surg, Cardiovasc Res Ctr, Ann Arbor, MI 48109 USA
7.Univ Texas Southwestern Med Ctr Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
8.Chinese Acad Sci, Ctr Precis Translat Med, Wuhan Inst Virol, Wuhan 430071, Peoples R China
9.Chinese Acad Sci, Guangzhou Women & Childrens Med Ctr, Wuhan Inst Virol, Wuhan 430071, Peoples R China
10.Chinese Acad Sci, Inst Pasteur Shanghai, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 He, Xiaomeng,Yu, Junjing,Wang, Min,et al. Bap180/baf180 is required to maintain homeostasis of intestinal innate immune response in drosophila and mice[J]. Nature microbiology,2017,2(6):13.
APA He, Xiaomeng.,Yu, Junjing.,Wang, Min.,Cheng, Yang.,Han, Yanan.,...&Tang, Hong.(2017).Bap180/baf180 is required to maintain homeostasis of intestinal innate immune response in drosophila and mice.Nature microbiology,2(6),13.
MLA He, Xiaomeng,et al."Bap180/baf180 is required to maintain homeostasis of intestinal innate immune response in drosophila and mice".Nature microbiology 2.6(2017):13.

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来源：武汉病毒研究所

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