Human virus-derived small rnas can confer antiviral immunity in mammals
文献类型：期刊论文
| 作者 | Qiu, Yang1,2,3; Xu, Yanpeng2; Zhang, Yao4; Zhou, Hui1,3; Deng, Yong-Qiang2; Li, Xiao-Feng2; Miao, Meng1,3; Zhang, Qiang1; Zhong, Bo1; Hu, Yuanyang1 |
| 刊名 | Immunity
 |
| 出版日期 | 2017-06-20 |
| 卷号 | 46期号:6页码:992-+ |
| ISSN号 | 1074-7613 |
| DOI | 10.1016/j.immuni.2017.05.006 |
| 通讯作者 | Qin, cheng-feng(qincf@bmi.ac.cn) ; Zhou, xi(zhouxi@wh.iov.cn) |
| 英文摘要 | Rna interference (rnai) functions as a potent antiviral immunity in plants and invertebrates; however, whether rnai plays antiviral roles in mammals remains unclear. here, using human enterovirus 71 (hev71) as a model, we showed hev71 3a protein as an authentic viral suppressor of rnai during viral infection. when the 3a-mediated rnai suppression was impaired, the mutant hev71 readily triggered the production of abundant hev71-derived small rnas with canonical sirna properties in cells and mice. these virus-derived sirnas were produced from viral dsrna replicative intermediates in a dicer-dependent manner and loaded into ago, and they were fully active in degrading cognate viral rnas. recombinant hev71 deficient in 3a-mediated rnai suppression was significantly restricted in human somatic cells and mice, whereas dicer deficiency rescued hev71 infection independently of type i interferon response. thus, rnai can function as an antiviral immunity, which is induced and suppressed by a human virus, in mammals. |
| WOS关键词 | INFLUENZA-A VIRUS ; MOUSE OOCYTES ; PROTEIN 3A ; CELLS ; INTERFERENCE ; REPLICATION ; SUPPRESSION ; INHIBITION ; INDUCTION ; DICER |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000403665900013 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373417 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Qin, Cheng-Feng; Zhou, Xi |
| 作者单位 | 1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China 2.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, Lab RNA Virol, Wuhan 430071, Hubei, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China 5.Guangzhou Med Univ, Guangzhou Peoples Hosp 8, Guangzhou 510060, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Yang,Xu, Yanpeng,Zhang, Yao,et al. Human virus-derived small rnas can confer antiviral immunity in mammals[J]. Immunity,2017,46(6):992-+. |
| APA | Qiu, Yang.,Xu, Yanpeng.,Zhang, Yao.,Zhou, Hui.,Deng, Yong-Qiang.,...&Zhou, Xi.(2017).Human virus-derived small rnas can confer antiviral immunity in mammals.Immunity,46(6),992-+. |
| MLA | Qiu, Yang,et al."Human virus-derived small rnas can confer antiviral immunity in mammals".Immunity 46.6(2017):992-+. |
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来源：武汉病毒研究所
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