Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses
文献类型：期刊论文
| 作者 | Tan, Bing1,2; Yang, Xing-Lou1; Ge, Xing-Yi1; Peng, Cheng1; Liu, Hai-Zhou1; Zhang, Yun-Zhi3; Zhang, Li-Biao4; Shi, Zheng-Li1,2 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 98期号:4页码:739-748 |
| 关键词 | Bat adenovirus G plus c content Cpg methylation Base composition Genome length |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/jgv.0.000739 |
| 通讯作者 | Shi, zheng-li(zlshi@wh.iov.cn) |
| 英文摘要 | Bats have been reported to carry diverse adenoviruses. however, most bat adenoviruses have been identified on the basis of partial genome sequences, and knowledge on the evolution of bat adenoviruses remains limited. in this study, we isolated and characterized four novel adenoviruses from two distinct bat species, and their full-length genomes were sequenced. sequence analysis revealed that these isolates represented three distinct species of the genus mastadenovirus. however, all isolates had an exceptionally low g+c content and relatively short genomes compared with other known mastadenoviruses. we further analysed the relationships among the g+c content, 5'- c-phosphate- g-3' (cpg) representation and genome size in the family adenoviridae. our results revealed that the cpg representation in adenoviral genomes depends primarily on the level of methylation, and the genome size displayed significant positive correlations with both g+c content and cpg representation. since ancestral adenoviruses are believed to have contained short genomes, those probably had a low g+c content, similar to the genomes of these bat strains. our results suggest that bats are important natural reservoirs for adenoviruses and play important roles in the evolution of adenoviruses. |
| WOS关键词 | GENETIC DIVERSITY ; GENOME ANALYSIS ; CODON USAGE ; DNA VIRUSES ; E3 GENES ; METHYLATION ; CHINA |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000401905000024 |
| 出版者 | MICROBIOLOGY SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373431 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Shi, Zheng-Li |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, CAS Key Lab Special Pathogens & Biosafety, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Yunnan Inst Endem Dis Control & Prevent, Yunnan Prov Key Lab Zoonosis Control & Prevent, Dali, Peoples R China 4.Guangdong Inst Appl Biol Resource, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Bing,Yang, Xing-Lou,Ge, Xing-Yi,et al. Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses[J]. Journal of general virology,2017,98(4):739-748. |
| APA | Tan, Bing.,Yang, Xing-Lou.,Ge, Xing-Yi.,Peng, Cheng.,Liu, Hai-Zhou.,...&Shi, Zheng-Li.(2017).Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses.Journal of general virology,98(4),739-748. |
| MLA | Tan, Bing,et al."Novel bat adenoviruses with low g plus c content shed new light on the evolution of adenoviruses".Journal of general virology 98.4(2017):739-748. |
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来源：武汉病毒研究所
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