Antiviral activity of peptide inhibitors derived from the protein e stem against japanese encephalitis and zika viruses
文献类型：期刊论文
| 作者 | Chen, Liman1,2; Liu, Yang1; Wang, Shaobo1,2; Sun, Jianhong1,2; Wang, Peilin1,2; Xin, Qilin1,2; Zhang, Leike1,2; Xiao, Gengfu1,2; Wang, Wei1,2 |
| 刊名 | Antiviral research
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 141页码:140-149 |
| 关键词 | Peptide inhibitors Japanese encephalitis virus Zika virus Glycoprotein Stem |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2017.02.009 |
| 通讯作者 | Wang, wei(wangwei@wh.iov.cn) |
| 英文摘要 | Japanese encephalitis virus (iev) and zika virus (zikv) are mosquito-borne viruses of the flavivirus genus that cause viral encephalitis and congenital microcephaly, respectively, in humans, and thus present a risk to global public health. the envelope glycoprotein (e protein) of fiaviviruses is a class ii viral fusion protein that mediates host cell entry through a series of conformational changes, including association between the stem region and domain ii leading to virion-target cell membrane fusion. in this study, peptides derived from the jev e protein stem were investigated for their ability to block jev and zikv infection. peptides from stem helix 2 inhibit jev infection with the 50% inhibitory concentration (ic50) in the nanomolar range. one of these peptides (p5) protected mice against jev-induced lethality by decreasing viral load, while abrogating histopathological changes associated with jev infection. we also found that p5 blocked zikv infection with ic50 at the micromolar level. moreover, p5 was proved to reduce the histopathological damages in brain and testes resulting from zikv infection in type i and ii interferon receptor-deficient (ag6) mice. these findings provide a basis for the development of peptide based drugs against jev and zikv. (c) 2017 elsevier b.v. all rights reserved. |
| WOS关键词 | WEST-NILE-VIRUS ; DENGUE VIRUS ; MEMBRANE-FUSION ; DOMAIN-III ; MUTATIONAL ANALYSIS ; ENVELOPE PROTEIN ; MOUSE MODEL ; FLAVIVIRUS ; ENTRY ; INFECTION |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| WOS类目 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000399506200015 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373444 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Xiaohongshan 44, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Liman,Liu, Yang,Wang, Shaobo,et al. Antiviral activity of peptide inhibitors derived from the protein e stem against japanese encephalitis and zika viruses[J]. Antiviral research,2017,141:140-149. |
| APA | Chen, Liman.,Liu, Yang.,Wang, Shaobo.,Sun, Jianhong.,Wang, Peilin.,...&Wang, Wei.(2017).Antiviral activity of peptide inhibitors derived from the protein e stem against japanese encephalitis and zika viruses.Antiviral research,141,140-149. |
| MLA | Chen, Liman,et al."Antiviral activity of peptide inhibitors derived from the protein e stem against japanese encephalitis and zika viruses".Antiviral research 141(2017):140-149. |
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来源：武汉病毒研究所
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