The roles of ebolavirus glycoproteins in viral pathogenesis
文献类型：期刊论文
| 作者 | Ning, Yun-Jia; Deng, Fei; Hu, Zhihong; Wang, Hualin |
| 刊名 | Virologica sinica
 |
| 出版日期 | 2017-02-01 |
| 卷号 | 32期号:1页码:3-15 |
| 关键词 | Ebolavirus Glycoprotein (gp) Mucin-like domain (mld) Cytotoxicity Immune evasion Inflammation Pathogenesis |
| ISSN号 | 1674-0769 |
| DOI | 10.1007/s12250-016-3850-1 |
| 通讯作者 | Wang, hualin(h.wang@wh.iov.cn) |
| 英文摘要 | Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in humans and nonhuman primates. the majority of ebolavirus species, most notably zaire ebolavirus, can cause ebola virus disease (evd), formerly known as ebola hemorrhagic fever, in humans. evd is associated with case-fatality rates as high as 90%, and there is currently no specific treatment or licensed vaccine available against evd. understanding the molecular biology and pathogenesis of ebolaviruses is important for the development of antiviral therapeutics. ebolavirus encodes several forms of glycoproteins (gps), which have some interesting characteristics, including the transcriptional editing coding strategy and extensive o-glycosylation modification, clustered in the mucin-like domain of gp1, full-length gp (gp(1,2)), and shed gp. in addition to the canonical role of the spike protein, gp(1,2), in viral entry, ebolavirus gps appear to have multiple additional functions, likely contributing to the complex pathogenesis of the virus. here, we review the roles of ebolavirus gps in viral pathogenesis. |
| WOS关键词 | VIRUS-LIKE PARTICLES ; INNATE IMMUNE EVASION ; NIEMANN-PICK C1 ; HEMORRHAGIC-FEVER ; DENDRITIC CELLS ; NEUTRALIZING ANTIBODIES ; MARBURG VIRUSES ; DELTA-PEPTIDE ; ENVELOPE GLYCOPROTEIN ; SURFACE GLYCOPROTEIN |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000396155400002 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373449 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Wang, Hualin |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ning, Yun-Jia,Deng, Fei,Hu, Zhihong,et al. The roles of ebolavirus glycoproteins in viral pathogenesis[J]. Virologica sinica,2017,32(1):3-15. |
| APA | Ning, Yun-Jia,Deng, Fei,Hu, Zhihong,&Wang, Hualin.(2017).The roles of ebolavirus glycoproteins in viral pathogenesis.Virologica sinica,32(1),3-15. |
| MLA | Ning, Yun-Jia,et al."The roles of ebolavirus glycoproteins in viral pathogenesis".Virologica sinica 32.1(2017):3-15. |
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来源：武汉病毒研究所
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