Nanoparticle-based b-cell targeting vaccines: tailoring of humoral immune responses by functionalization with different tlr-ligands
文献类型：期刊论文
| 作者 | Zilker, Claudia1; Kozlova, Diana2,3; Sokolova, Viktoriya2,3; Yan, Huimin4; Epple, Matthias2,3; Ueberla, Klaus1,5; Temchura, Vladimir1,5 |
| 刊名 | Nanomedicine-nanotechnology biology and medicine
 |
| 出版日期 | 2017 |
| 卷号 | 13期号:1页码:173-182 |
| 关键词 | Calcium phosphate Nanoparticles B-cell activation Tlr ligands |
| ISSN号 | 1549-9634 |
| DOI | 10.1016/j.nano.2016.08.028 |
| 通讯作者 | Temchura, vladimir(temchura@yandex.com) |
| 英文摘要 | Induction of an appropriate type of humoral immune response during vaccination is essential for protection against viral and bacterial infections. we recently observed that biodegradable calcium phosphate (cap) nanoparticles coated with proteins efficiently targeted and activated naive antigen-specific b-cells in vitro. we now compared different administration routes for cap-nanoparticles and demonstrated that intramuscular immunization with such cap-nanoparticles induced stronger immune responses than immunization with monovalent antigen. additional functionalization of the cap-nanoparticles with trl-ligands allowed modulating the igg subtype response and the level of mucosal iga antibodies. cpg-containing cap-nanoparticles were as immunogenic as a virus-like particle vaccine. functionalization of cap-nanoparticles with t-helper cell epitopes or cpg also allowed overcoming lack of t-cell help. thus, our results indicate that cap-nanoparticle- based b-cell targeting vaccines functionalized with tlr-ligands can serve as a versatile platform for efficient induction and modulation of humoral immune responses in vivo. (c) 2016 elsevier inc. all rights reserved. |
| WOS关键词 | VIRUS-LIKE PARTICLES ; CALCIUM-PHOSPHATE NANOPARTICLES ; TOLL-LIKE RECEPTORS ; EGG-WHITE LYSOZYME ; PROLIFERATIVE RESPONSES ; DENDRITIC CELLS ; ACTIVATION ; ANTIGEN ; IMMUNIZATION ; PROTEIN |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| WOS类目 | Nanoscience & Nanotechnology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000396378200015 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373465 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Temchura, Vladimir |
| 作者单位 | 1.Ruhr Univ Bochum, Dept Mol & Med Virol, Bochum, Germany 2.Univ Duisburg Essen, Inorgan Chem, Essen, Germany 3.Univ Duisburg Essen, Ctr Nanointegrat Duisburg Essen CeNIDE, Essen, Germany 4.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Mucosal Immun Res Grp, Wuhan, Peoples R China 5.Friedrich Alexander Univ Erlangen Nurnberg FAU, Inst Clin & Mol Virol, Univ Hosp Erlangen, Erlangen, Germany |
| 推荐引用方式 GB/T 7714 | Zilker, Claudia,Kozlova, Diana,Sokolova, Viktoriya,et al. Nanoparticle-based b-cell targeting vaccines: tailoring of humoral immune responses by functionalization with different tlr-ligands[J]. Nanomedicine-nanotechnology biology and medicine,2017,13(1):173-182. |
| APA | Zilker, Claudia.,Kozlova, Diana.,Sokolova, Viktoriya.,Yan, Huimin.,Epple, Matthias.,...&Temchura, Vladimir.(2017).Nanoparticle-based b-cell targeting vaccines: tailoring of humoral immune responses by functionalization with different tlr-ligands.Nanomedicine-nanotechnology biology and medicine,13(1),173-182. |
| MLA | Zilker, Claudia,et al."Nanoparticle-based b-cell targeting vaccines: tailoring of humoral immune responses by functionalization with different tlr-ligands".Nanomedicine-nanotechnology biology and medicine 13.1(2017):173-182. |
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来源：武汉病毒研究所
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