25-hydroxycholesterol protects host against zika virus infection and its associated microcephaly in a mouse model
文献类型：期刊论文
| 作者 | Li, Chunfeng1,2,3,4; Deng, Yong-Qiang4; Wang, Shuo5,6; Ma, Feng1,2,3,7; Aliyari, Roghiyh7; Huang, Xing-Yao4; Zhang, Na-Na4,8; Watanabe, Momoko9,10; Dong, Hao-Long4; Liu, Ping11 |
| 刊名 | Immunity
 |
| 出版日期 | 2017-03-21 |
| 卷号 | 46期号:3页码:446-456 |
| ISSN号 | 1074-7613 |
| DOI | 10.1016/j.immuni.2017.02.012 |
| 通讯作者 | Novitch, bennett g.(bnovitch@ucla.edu) ; Xu, zhiheng(zhxu@genetics.ac.cn) ; Qin, cheng-feng(qincf@bmi.ac.cn) ; Cheng, genhong(gcheng@mednet.ucla.edu) |
| 英文摘要 | Zika virus (zikv) has become a public health threat due to its global transmission and link to severe congenital disorders. the host immune responses to zikv infection have not been fully elucidated, and effective therapeutics are not currently available. herein, we demonstrated that cholesterol-25-hydroxylase (ch25h) was induced in response to zikv infection and that its enzymatic product, 25-hydroxycholesterol (25hc), was a critical mediator of host protection against zikv. synthetic 25hc addition inhibited zikv infection in vitro by blocking viral entry, and treatment with 25hc reduced viremia and conferred protection against zikv in mice and rhesus macaques. 25hc suppressed zikv infection and reduced tissue damage in human cortical organoids and the embryonic brain of the zikv-induced mouse microcephaly model. our findings highlight the protective role of ch25h during zikv infection and the potential use of 25hc as a natural antiviral agent to combat zikv infection and prevent zikv-associated outcomes, such as microcephaly. |
| WOS关键词 | PLACENTAL TROPHOBLASTS ; DENGUE VIRUS ; MICE ; REPLICATION ; CHOLESTEROL ; MACROPHAGES ; OXYSTEROLS ; ATHEROSCLEROSIS ; IDENTIFICATION ; TRANSCRIPTION |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000396818100016 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373467 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Novitch, Bennett G.; Xu, Zhiheng; Qin, Cheng-Feng; Cheng, Genhong |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China 2.Peking Union Med Coll, Beijing 100005, Peoples R China 3.Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China 4.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Dept Virol, Beijing 100071, Peoples R China 5.Chinese Acad Sci, State Key Lab Mol Dev Biol, Ctr Excellence Brain Sci & Intelligence Technol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 6.Beijing Inst Brain Disorders, Parkinsons Dis Ctr, Beijing 100101, Peoples R China 7.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA 8.Guangxi Med Univ, Nanning 530021, Peoples R China 9.Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA 10.Univ Calif Los Angeles, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Li, Chunfeng,Deng, Yong-Qiang,Wang, Shuo,et al. 25-hydroxycholesterol protects host against zika virus infection and its associated microcephaly in a mouse model[J]. Immunity,2017,46(3):446-456. |
| APA | Li, Chunfeng.,Deng, Yong-Qiang.,Wang, Shuo.,Ma, Feng.,Aliyari, Roghiyh.,...&Cheng, Genhong.(2017).25-hydroxycholesterol protects host against zika virus infection and its associated microcephaly in a mouse model.Immunity,46(3),446-456. |
| MLA | Li, Chunfeng,et al."25-hydroxycholesterol protects host against zika virus infection and its associated microcephaly in a mouse model".Immunity 46.3(2017):446-456. |
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来源：武汉病毒研究所
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