Mita/sting and its alternative splicing isoform mrp restrict hepatitis b virus replication
文献类型：期刊论文
| 作者 | Liu, Shuhui1,2; Zhao, Kaitao1,2; Su, Xi1,2; Lu, Lu3,5; Zhao, He1; Zhang, Xianwen1,2; Wang, Yun1; Wu, Chunchen1; Chen, Jizheng1; Zhou, Yuan1 |
| 刊名 | Plos one
 |
| 出版日期 | 2017-01-05 |
| 卷号 | 12期号:1页码:20 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0169701 |
| 通讯作者 | Chen, xinwen(chenxw@wh.iov.cn) ; Pei, rongjuan(rongjuan_pei@wh.iov.cn) |
| 英文摘要 | An efficient clearance of hepatitis b virus (hbv) requires the coordinated work of both the innate and adaptive immune responses. mita/sting, an adapter protein of the innate immune signaling pathways, plays a key role in regulating innate and adaptive immune responses to dna virus infection. previously, we identified an alternatively spliced isoform of mita/sting, called mita-related protein (mrp), and found that mrp could specifically block mita-mediated interferon (ifn) induction while retaining the ability to activate nf-kappa b. here, we asked whether mita/sting and mrp were able to control the hbv replication. both mita/sting and mrp significantly inhibited hbv replication in vitro. mita overexpression stimulated irf3-ifn pathway; while mrp overexpression activated nf-kappa b pathway, suggesting these two isoforms may inhibit hbv replication through different ways. using a hydrodynamic injection (hi) mouse model, we found that hbv replication was reduced following mita/sting and mrp expression vectors in mice and was enhanced by the knockout of mita/sting (mita/sting(-/-)). the hbv specific humoral and cd8(+) t cell responses were impaired in mita/sting deficient mice, suggesting the participation of mita/sting in the initiation of host adaptive immune responses. in summary, our data suggest that mita/sting and mrp contribute to hbv control via modulation of the innate and adaptive responses. |
| WOS关键词 | CYCLIC GMP-AMP ; AMINO-ACID SUBSTITUTIONS ; INNATE IMMUNE-RESPONSE ; VIVO HBSAG CLEARANCE ; TOLL-LIKE RECEPTORS ; NF-KAPPA-B ; RIG-I ; INTRACELLULAR DNA ; CYTOSOLIC DNA ; ADAPTIVE IMMUNITY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000391639100069 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373477 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Xinwen; Pei, Rongjuan |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Microbiol, Wuhan, Peoples R China 4.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Essen, Germany 5.Jiangdong Ctr Dis Control & Prevent, Ningbo, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shuhui,Zhao, Kaitao,Su, Xi,et al. Mita/sting and its alternative splicing isoform mrp restrict hepatitis b virus replication[J]. Plos one,2017,12(1):20. |
| APA | Liu, Shuhui.,Zhao, Kaitao.,Su, Xi.,Lu, Lu.,Zhao, He.,...&Pei, Rongjuan.(2017).Mita/sting and its alternative splicing isoform mrp restrict hepatitis b virus replication.Plos one,12(1),20. |
| MLA | Liu, Shuhui,et al."Mita/sting and its alternative splicing isoform mrp restrict hepatitis b virus replication".Plos one 12.1(2017):20. |
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来源：武汉病毒研究所
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