Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export
文献类型：期刊论文
| 作者 | Mu, Jingfang1,2,5; Zhang, Yongli1,2; Hu, Yangyang1,2; Hu, Xue1; Zhou, Yuan1; Zhao, He1; Pei, Rongjuan1; Wu, Chunchen1; Chen, Jizheng1; Zhao, Han1,2 |
| 刊名 | Plos pathogens
 |
| 出版日期 | 2016-11-01 |
| 卷号 | 12期号:11页码:22 |
| ISSN号 | 1553-7366 |
| DOI | 10.1371/journal.ppat.1005994 |
| 通讯作者 | Chen, xinwen(chenxw@wh.iov.cn) ; Wang, yun(wangyun@wh.iov.cn) |
| 英文摘要 | Actin, nucleation-promoting factors (npfs), and the actin-related protein 2/3 complex (arp2/3) are key elements of the cellular actin polymerization machinery. with nuclear actin polymerization implicated in ever-expanding biological processes and the discovery of the nuclear import mechanisms of actin and npfs, determining arp2/3 nucleo-cytoplasmic shuttling mechanism is important for understanding the function of nuclear actin. a unique feature of alphabaculovirus infection of insect cells is the robust nuclear accumulation of arp2/3, which induces actin polymerization in the nucleus to assist in virus replication. we found that ac34, a viral late gene product encoded by the alphabaculovirus autographa californica multiple nucleopolyhedrovirus (acmnpv), is involved in arp2/3 nuclear accumulation during virus infection. further assays revealed that the subcellular distribution of arp2/3 under steady-state conditions is controlled by chromosomal maintenance 1 (crm1)-dependent nuclear export. upon acmnpv infection, ac34 inhibits crm1 pathway and leads to arp2/3 retention in the nucleus. |
| WOS关键词 | HELICOVERPA-ARMIGERA NUCLEOPOLYHEDROVIRUS ; MAJOR CAPSID PROTEIN ; ARP2/3 COMPLEX ; PORE COMPLEX ; NUCLEOCYTOPLASMIC TRANSPORT ; NUCLEOCAPSID PROTEIN ; POLYHEDROSIS-VIRUS ; IMPORT RECEPTORS ; F-ACTIN ; MOTILITY |
| WOS研究方向 | Microbiology ; Parasitology ; Virology |
| WOS类目 | Microbiology ; Parasitology ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000392193200027 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373479 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Xinwen; Wang, Yun |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Sun Yat Sen Univ, State Key Lab Biocontrol, Guangzhou, Guangdong, Peoples R China 4.Wageningen Univ, Virol Lab, Wageningen, Netherlands 5.Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mu, Jingfang,Zhang, Yongli,Hu, Yangyang,et al. Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export[J]. Plos pathogens,2016,12(11):22. |
| APA | Mu, Jingfang.,Zhang, Yongli.,Hu, Yangyang.,Hu, Xue.,Zhou, Yuan.,...&Wang, Yun.(2016).Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export.Plos pathogens,12(11),22. |
| MLA | Mu, Jingfang,et al."Autographa californica multiple nucleopolyhedrovirus ac34 protein retains cellular actin-related protein 2/3 complex in the nucleus by subversion of crm1-dependent nuclear export".Plos pathogens 12.11(2016):22. |
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来源：武汉病毒研究所
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