Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine
文献类型：期刊论文
| 作者 | Sun,Zhao1; Wang,Wei2; Wang,Rui3; Duan,Jinhong2; Hu,Yan2; Ma,Jin2; Zhou,Jiayan2; Xie,Sishen4; Lu,Xin1; Zhu,Zhaohui1 |
| 刊名 | Cancer nanotechnology
 |
| 出版日期 | 2010-05-07 |
| 卷号 | 1期号:1-6 |
| 关键词 | Aluminum Nanoparticle Anticancer Immune adjuvant |
| ISSN号 | 1868-6958 |
| DOI | 10.1007/s12645-010-0001-5 |
| 通讯作者 | Xu,haiyan(xuhy@pumc.edu.cn) ; Wang,chen(wangch@iccas.ac.cn) ; Yang,xian-da(ayangmd@gmail.com) |
| 英文摘要 | Abstractthe application of nanomaterial in cancer treatment is promising and intriguing. anti-tumor immunotherapy has the potential to significantly improve the prognosis of cancer treatment, though the efficacy of immunotherapy generally needs further improvement. one way to improve the efficacy is using immune adjuvants, but the adjuvants for anticancer immunotherapy have to be more potent than for prophylactic vaccines. here, we report that compared to conventional alum adjuvant, aluminum oxide nanoparticles (nano-alum) may further enhance the anticancer effects of an immunotherapy that employs tumor cell vaccine (tcv). the average tumor size tends to be lower in animals that receive the combinational treatment of nano-alum and tcv. the anticancer cytotoxicity by the lymphocytes was also significantly higher in the treatment group that received both tcv and nano-alum. these results suggest that nano-alum may potentially serve as a potent immune adjuvant and have prospective applications in anticancer immunotherapy. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1007/S12645-010-0001-5 |
| 出版者 | Springer Vienna |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373545 |
| 专题 | 物理研究所 |
| 通讯作者 | Xu,Haiyan; Wang,Chen; Yang,Xian-Da |
| 作者单位 | 1.Peking Union Medical College Hospital 2.Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences 3.National Center of Nanoscience and Technology 4.Institute of Physics, Chinese Academy of Sciences 5.Beijing TianTan Hospital |
| 推荐引用方式 GB/T 7714 | Sun,Zhao,Wang,Wei,Wang,Rui,et al. Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine[J]. Cancer nanotechnology,2010,1(1-6). |
| APA | Sun,Zhao.,Wang,Wei.,Wang,Rui.,Duan,Jinhong.,Hu,Yan.,...&Yang,Xian-Da.(2010).Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine.Cancer nanotechnology,1(1-6). |
| MLA | Sun,Zhao,et al."Aluminum nanoparticles enhance anticancer immune response induced by tumor cell vaccine".Cancer nanotechnology 1.1-6(2010). |
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来源：物理研究所
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