Anticonvulsant effect of bmk it2, a sodium channel-specific neurotoxin, in rat models of epilepsy
文献类型：期刊论文
| 作者 | Zhao, R.2; Zhang, X-Y3; Yang, J.1; Weng, C-C1; Jiang, L-L1; Zhang, J-W1; Shu, X-Q1; Ji, Y-H1 |
| 刊名 | British journal of pharmacology
 |
| 出版日期 | 2008-07-01 |
| 卷号 | 154期号:5页码:1116-1124 |
| ISSN号 | 0007-1188 |
| 关键词 | Bmk it2 Intrahippocampal injection Status epilepticus Epileptic seizures Sodium channels |
| DOI | 10.1038/bjp.2008.156 |
| 通讯作者 | Ji, y-h(yhji@staff.shu.edu.cn) |
| 英文摘要 | Background and purpose: the sodium channel is a primary target for treating central nervous system disorders such as epilepsy. in this study the anticonvulsant effect of bmk it2, a sodium channel-specific neurotoxin, was evaluated in different animal models of epilepsy. experimental approach: experiments were performed on freely moving rats made epileptic by administration of either pentylenetetrazole (ptz) or pilocarpine. bmk it2 (0.05-0.5 mu g in 2 mu l) was microinjected into the ca1 area and its effects on ptz-induced widespread, seizure-like behaviour and cortex epileptiform eeg, as well as on pilocarpine-induced seizure-like behaviour and c-fos expression were studied. key results: intrahippocampal application of bmk it2 dose-dependently inhibited ptz-induced seizure-like behaviour, and reduced the numbers and duration of the high amplitude and frequency discharges (hafds) of the epileptiform eeg component induced by ptz. similarly, in the pilocarpine-induced status epilepticus (se) model, bmk it2 significantly prolonged the latency to onset of the se, reduced the severity of se and suppressed hippocampal c-fos expression during se. conclusions and implications: bmk it2 showed anticonvulsant activity as it inhibited the widespread seizures induced by ptz and pilocarpine-induced se in rats. this activity might be due to the modulation of sodium channels in the hippocampus. hence, bmk it2 could be used as a novel tool to explore the molecular and pathological mechanisms of epilepsy with regard to the involvement of sodium channels. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; TEMPORAL-LOBE EPILEPSY ; C-FOS EXPRESSION ; STATUS EPILEPTICUS ; SCORPION NEUROTOXIN ; ANTIEPILEPTIC DRUGS ; INDUCED SEIZURES ; NERVOUS-SYSTEM ; ANIMAL-MODELS ; IN-VITRO |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000257269400021 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373696 |
| 专题 | 物理研究所 |
| 通讯作者 | Ji, Y-H |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Grad Sch, Inst Phys, Shanghai Inst Biol Sci, Shanghai, Peoples R China 3.Natl Inst Environm Hlth Sci, Membrane Signaling Grp, Neurobiol Lab, Natl Inst Hlth, Res Triangle Pk, NC 27709 USA |
| 推荐引用方式 GB/T 7714 | Zhao, R.,Zhang, X-Y,Yang, J.,et al. Anticonvulsant effect of bmk it2, a sodium channel-specific neurotoxin, in rat models of epilepsy[J]. British journal of pharmacology,2008,154(5):1116-1124. |
| APA | Zhao, R..,Zhang, X-Y.,Yang, J..,Weng, C-C.,Jiang, L-L.,...&Ji, Y-H.(2008).Anticonvulsant effect of bmk it2, a sodium channel-specific neurotoxin, in rat models of epilepsy.British journal of pharmacology,154(5),1116-1124. |
| MLA | Zhao, R.,et al."Anticonvulsant effect of bmk it2, a sodium channel-specific neurotoxin, in rat models of epilepsy".British journal of pharmacology 154.5(2008):1116-1124. |
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