A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes
文献类型：期刊论文
| 作者 | Du, Pengcheng2; Yang, Yinxue3; Wang, Haiying2; Liu, Di4; Gao, George F.1,5; Chen, Chen2 |
| 刊名 | Bmc microbiology
 |
| 出版日期 | 2011-06-15 |
| 卷号 | 11页码:7 |
| 关键词 | Switch sites of gc-skew Genomic island Evolution |
| ISSN号 | 1471-2180 |
| DOI | 10.1186/1471-2180-11-135 |
| 通讯作者 | Gao, george f.(gaof@im.ac.cn) |
| 英文摘要 | Background: bacterial virulence enhancement and drug resistance are major threats to public health worldwide. interestingly, newly acquired genomic islands (gis) from horizontal transfer between different bacteria strains were found in vibrio cholerae, streptococcus suis, and mycobacterium tuberculosis, which caused outbreak of epidemic diseases in recently years. results: using a large-scale comparative genomic analysis of 1088 complete genomes from all available bacteria (1009) and archaea (79), we found that newly acquired gis are often anchored around switch sites of gc-skew (sgcs). after calculating correlations between relative genomic distances of genomic islands to sgcss and the evolutionary distances of the genomic islands themselves, we found that newly acquired genomic islands are closer to sgcss than the old ones, indicating that regions around sgcss are hotspots for genomic island insertion. conclusions: based on our results, we believe that genomic regions near sgcss are hotspots for horizontal transfer of genomic islands, which may significantly affect key properties of epidemic disease-causing pathogens, such as virulence and adaption to new environments. |
| WOS关键词 | REPLICATION ORIGINS ; HAPLOTYPE BLOCKS ; VIBRIO-CHOLERAE ; GC SKEW ; PATHOGENICITY ; EVOLUTION ; CHROMOSOMES ; TRANSCRIPTION ; ASYMMETRY ; MICROBES |
| WOS研究方向 | Microbiology |
| WOS类目 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000293474000001 |
| 出版者 | BIOMED CENTRAL LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374138 |
| 专题 | 计算机网络信息中心 |
| 通讯作者 | Gao, George F. |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 2.Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China 3.Ningxia Med Univ, Affiliated Hosp, Ningxia 750001, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, Network Informat Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Pengcheng,Yang, Yinxue,Wang, Haiying,et al. A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes[J]. Bmc microbiology,2011,11:7. |
| APA | Du, Pengcheng,Yang, Yinxue,Wang, Haiying,Liu, Di,Gao, George F.,&Chen, Chen.(2011).A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes.Bmc microbiology,11,7. |
| MLA | Du, Pengcheng,et al."A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes".Bmc microbiology 11(2011):7. |
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来源：计算机网络信息中心
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