Vcgdb: a dynamic genome database of the chinese population
文献类型：期刊论文
| 作者 | Ling,Yunchao1,2; Jin,Zhong3; Su,Mingming1,2; Zhong,Jun1,2; Zhao,Yongbing1,2; Yu,Jun1; Wu,Jiayan1; Xiao,Jingfa1 |
| 刊名 | Bmc genomics
 |
| 出版日期 | 2014-04-05 |
| 卷号 | 15期号:1 |
| 关键词 | Chinese population Dynamic genome Database 1000 genomes project Big data |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/1471-2164-15-265 |
| 通讯作者 | Yu,jun(junyu@big.ac.cn) ; Wu,jiayan(wujy@big.ac.cn) ; Xiao,jingfa(xiaojingfa@big.ac.cn) |
| 英文摘要 | Abstractbackgroundthe data released by the 1000 genomes project contain an increasing number of genome sequences from different nations and populations with a large number of genetic variations. as a result, the focus of human genome studies is changing from single and static to complex and dynamic. the currently available human reference genome (grch37) is based on sequencing data from 13 anonymous caucasian volunteers, which might limit the scope of genomics, transcriptomics, epigenetics, and genome wide association studies.descriptionwe used the massive amount of sequencing data published by the 1000 genomes project consortium to construct the virtual chinese genome database (vcgdb), a dynamic genome database of the chinese population based on the whole genome sequencing data of 194 individuals. vcgdb provides dynamic genomic information, which contains 35 million single nucleotide variations (snvs), 0.5 million insertions/deletions (indels), and 29 million rare variations, together with genomic annotation information. vcgdb also provides a highly interactive user-friendly virtual chinese genome browser (vcgbrowser) with functions like seamless zooming and real-time searching. in addition, we have established three population-specific consensus chinese reference genomes that are compatible with mainstream alignment software.conclusionsvcgdb offers a feasible strategy for processing big data to keep pace with the biological data explosion by providing a robust resource for genomics studies; in particular, studies aimed at finding regions of the genome associated with diseases. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/1471-2164-15-265 |
| 出版者 | BioMed Central |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374155 |
| 专题 | 计算机网络信息中心 |
| 通讯作者 | Yu,Jun; Wu,Jiayan; Xiao,Jingfa |
| 作者单位 | 1.Chinese Academy of Sciences; CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics 2.University of Chinese Academy of Sciences 3.Chinese Academy of Sciences; Computer Network Information Center |
| 推荐引用方式 GB/T 7714 | Ling,Yunchao,Jin,Zhong,Su,Mingming,et al. Vcgdb: a dynamic genome database of the chinese population[J]. Bmc genomics,2014,15(1). |
| APA | Ling,Yunchao.,Jin,Zhong.,Su,Mingming.,Zhong,Jun.,Zhao,Yongbing.,...&Xiao,Jingfa.(2014).Vcgdb: a dynamic genome database of the chinese population.Bmc genomics,15(1). |
| MLA | Ling,Yunchao,et al."Vcgdb: a dynamic genome database of the chinese population".Bmc genomics 15.1(2014). |
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来源：计算机网络信息中心
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