A new reassortment of influenza a (h7n9) virus causing human infection in beijing, 2014
文献类型：期刊论文
| 作者 | Bi, Yuhai1,2,3; Liu, Jingyuan4; Xiong, Haofeng4; Zhang, Yue5,6; Liu, Di2,3,7; Liu, Yingxia1; Gao, George F.1,2,3; Wang, Beibei5,6 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-05-27 |
| 卷号 | 6页码:8 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep26624 |
| 通讯作者 | Wang, beibei(beibeiwang@ccmu.edu.cn) |
| 英文摘要 | A 73-year-old man was confirmed to have an influenza a (h7n9) virus infection, and the causative agent a/beijing/02/2014(h7n9) virus was isolated. genetic and phylogenetic analyses revealed that the virus belonged to a novel genotype, which probably emerged and further reassorted with other h9 or h7 viruses in poultry before transmitting to humans. this virus caused a severe infection with high levels of cytokines and neutralizing antibodies. eventually, the patient was cured after serially combined treatments. taken together, our findings indicated that this novel genotype of the human h7n9 virus did not evolve directly from the first beijing isolate a/beijing/01/2013(h7n9), suggesting that the h7n9 virus has not obtained the ability for human-to-human transmissibility and the virus only evolves in poultry and then infects human by direct contact. hence, the major measures to prevent human h7n9 virus infection are still to control and standardize the live poultry trade. early antiviral treatment with combination therapies, including mechanical ventilation, nutrition support and symptomatic treatment, are effective for h7n9 infection. |
| WOS关键词 | AVIAN INFLUENZA ; CYTOKINE STORM ; A(H7N9) VIRUS ; CHINA ; HYPERCYTOKINEMIA ; PATHOGENICITY ; SURVEILLANCE ; DYSFUNCTION ; INDUCTION ; SEVERITY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000376690000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374180 |
| 专题 | 计算机网络信息中心 |
| 通讯作者 | Wang, Beibei |
| 作者单位 | 1.Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 4.Capital Med Univ, Beijing Ditan Hosp, Intens Care Unit, Beijing 100015, Peoples R China 5.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100015, Peoples R China 6.Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China 7.Chinese Acad Sci, Network Informat Ctr, Inst Microbiol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bi, Yuhai,Liu, Jingyuan,Xiong, Haofeng,et al. A new reassortment of influenza a (h7n9) virus causing human infection in beijing, 2014[J]. Scientific reports,2016,6:8. |
| APA | Bi, Yuhai.,Liu, Jingyuan.,Xiong, Haofeng.,Zhang, Yue.,Liu, Di.,...&Wang, Beibei.(2016).A new reassortment of influenza a (h7n9) virus causing human infection in beijing, 2014.Scientific reports,6,8. |
| MLA | Bi, Yuhai,et al."A new reassortment of influenza a (h7n9) virus causing human infection in beijing, 2014".Scientific reports 6(2016):8. |
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